遵循高血压饮食防治法与血清尿酸之间的关联。

Association between adherence to the Dietary Approaches to Stop Hypertension diet and serum uric acid.

机构信息

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Health Management Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

Sci Rep. 2023 Apr 18;13(1):6347. doi: 10.1038/s41598-023-31762-x.

DOI:10.1038/s41598-023-31762-x

PMID:37072454

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10113210/

Abstract

To explore the relationship between Dietary Approaches to Stop Hypertension (DASH) diet and serum uric acid (SUA) levels among the Chinese adult population, and verify the mediating effect of BMI between DASH diet and SUA levels. A total of 1125 adults were investigated using a self-administered food frequency questionnaire. SUA levels were determined by uricase colorimetry. The total DASH score ranged from 9 to 72. The relationship between the DASH diet and SUA levels was examined by multiple adjusted regression analysis. Method of Bootstrap was used to test the mediation effect of BMI in the correlation of the DASH diet and SUA levels. After multivariable adjustment, there was a significant linear relationship between the DASH diet and SUA (P < 0.001). Compared with the lowest group, SUA of participants in group of highest DASH diet score decreased by 34.907 (95% CI - 52.227, - 17.588; P trend < 0.001) μmol/L. The association between the DASH diet scores and SUA levels was partly mediated by BMI (- 0.26, Bootstrap 95% CI - 0.49, - 0.07), with 10.53% of the total effect being mediated. Adopting the DASH diet might be helpful in reducing SUA level, and the effect might be partly mediated by BMI.

摘要

为了探究中国成年人中得舒饮食（DASH）与血清尿酸（SUA）水平之间的关系，并验证 BMI 在 DASH 饮食与 SUA 水平之间的中介作用，我们共调查了 1125 名成年人，采用了自我管理的食物频率问卷。尿酸酶比色法测定 SUA 水平。DASH 评分范围为 9 至 72。采用多元调整回归分析来研究 DASH 饮食与 SUA 水平之间的关系。采用 Bootstrap 方法来检验 BMI 在 DASH 饮食与 SUA 水平相关性中的中介作用。在多变量调整后，DASH 饮食与 SUA 之间存在显著的线性关系（P<0.001）。与最低组相比，DASH 饮食评分最高组的参与者的 SUA 降低了 34.907（95%CI-52.227，-17.588；P 趋势<0.001）μmol/L。DASH 饮食评分与 SUA 水平之间的关联部分由 BMI 介导（-0.26，Bootstrap 95%CI-0.49，-0.07），总效应的 10.53%由其介导。采用 DASH 饮食可能有助于降低 SUA 水平，且该效应可能部分由 BMI 介导。