γ-谷氨酰转移酶与高尿酸血症的横断面关联：中国多民族队列研究（CMEC）。

Cross-sectional association between gamma-glutamyl transferase and hyperuricaemia: the China Multi-Ethinic Cohort (CMEC) study.

机构信息

School of Public Health, Kunming Medical University, Kunming, Yunnan, China.

School of Public Health, Kunming Medical University, Kunming, Yunnan, China

出版信息

BMJ Open. 2022 May 30;12(5):e058793. doi: 10.1136/bmjopen-2021-058793.

DOI:10.1136/bmjopen-2021-058793

PMID:35636797

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9152940/

Abstract

OBJECTIVES

Several studies have demonstrated the association between gamma-glutamyl transferase (GGT) and hyperuricaemia, but little is known about such relation in less-developed ethnic minority regions.

DESIGN

We cross-sectionally analysed data from the China Multi-Ethnic Cohort (Yunnan region).

SETTING

Cross-sectional study.

PARTICIPANTS

22 020 participants aged 30-79 years from Han ethnicity, Yi ethnicity and Bai ethnicity.

OUTCOMES

The serum level of uric acid, GGT and other metabolic parameters were tested. Weight, height and blood pressure were measured. Smoking, drinking, ethnicity, education and medical history were obtained from questionnaires.

RESULTS

In the crude model, compared with the lowest quintile, the second, third, fourth and fifth quintiles of serum GGT exhibited a positive association with hyperuricaemia risk (OR=1.69, 2.90, 4.34 and 7.70, 95% CI=1.42 to 2.01, 2.47 to 3.42, 3.71 to 5.09 and 6.60 to 8.98, respectively, p-trend<0.0001). In fully adjusted model, compared with the lowest quintile, the second, third, fourth and fifth quintiles of serum GGT also exhibited a positive association with hyperuricaemia risk (OR=1.26, 1.68, 2.02 and 3.02, 95% CI=1.04 to 1.51, 1.40 to 2.00, 1.69 to 2.42 and 2.51 to 3.64, respectively, p-trend<0.0001). Logistic regression model was conducted separately in ethnic groups. Compared with first quintile, the highest GGT level were related to higher risk of hyperuricaemia in three ethnic groups (OR (95% CI): 2.89 (2.26 to 3.68), 2.81 (1.93 to 4.11) and 3.04 (1.91 to 4.84) for Han, Yi and Bai ethnicity, respectively, p-trend <0.0001). The relationship between GGT and hyperuricaemia was also observed in different age groups or gender groups.

CONCLUSIONS

High serum GGT level was related to a higher risk of hyperuricaemia in less-developed ethnic minority regions in China.

摘要

目的

已有多项研究表明γ-谷氨酰转移酶（GGT）与高尿酸血症之间存在关联，但在欠发达的少数民族地区，人们对此关联知之甚少。

设计

我们对来自中国多民族队列研究（云南地区）的数据进行了横断面分析。

地点

横断面研究。

参与者

年龄在 30-79 岁的汉族、彝族和白族 22020 名参与者。

结局

检测了血尿酸、GGT 及其他代谢参数。测量了体重、身高和血压。通过问卷获得了吸烟、饮酒、民族、教育程度和病史等信息。

结果

在未校正模型中，与最低五分位组相比，血清 GGT 的第二、三、四、五分位组与高尿酸血症风险呈正相关（OR=1.69、2.90、4.34 和 7.70，95%CI=1.42 至 2.01、2.47 至 3.42、3.71 至 5.09 和 6.60 至 8.98，P 趋势<0.0001）。在完全校正模型中，与最低五分位组相比，血清 GGT 的第二、三、四、五分位组与高尿酸血症风险也呈正相关（OR=1.26、1.68、2.02 和 3.02，95%CI=1.04 至 1.51、1.40 至 2.00、1.69 至 2.42 和 2.51 至 3.64，P 趋势<0.0001）。我们分别在不同民族中进行了 logistic 回归模型分析。与第一五分位组相比，GGT 最高水平与三个民族的高尿酸血症风险增加相关（OR（95%CI）：汉族 2.89（2.26 至 3.68）、彝族 2.81（1.93 至 4.11）和白族 3.04（1.91 至 4.84），P 趋势<0.0001）。在不同年龄组或性别组中也观察到了 GGT 与高尿酸血症之间的关系。