Qu Baozhen, Zhang Shicui, Ma Zengyu, Gao Zhan
Department of Marine Biology, Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, 266003 China.
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, 266237 China.
Mar Life Sci Technol. 2021 Jan 2;3(3):279-292. doi: 10.1007/s42995-020-00080-w. eCollection 2021 Aug.
The vertebrate liver is regarded as an organ essential to the regulation of immunity and inflammation as well as being central to the metabolism of nutrients. Here, we discuss the functions that the hepatic cecum of amphioxus plays in the regulation of immunity and inflammation, and the molecular basis of this. It is apparent that the hepatic cecum performs important roles in the immunity of amphioxus including immune surveillance, clearance of pathogens and acute phase response. Therefore, the hepatic cecum, like the vertebrate liver, is an organ functioning as a key integrator of immunity in amphioxus.
脊椎动物的肝脏被视为对免疫和炎症调节至关重要的器官，同时也是营养物质代谢的核心。在此，我们讨论文昌鱼肝盲囊在免疫和炎症调节中的作用及其分子基础。显然，肝盲囊在文昌鱼的免疫中发挥着重要作用，包括免疫监视、病原体清除和急性期反应。因此，肝盲囊与脊椎动物的肝脏一样，是文昌鱼中作为免疫关键整合器发挥作用的器官。
