Jones W G, Barie P S, Yurt R W, Goodwin C W
Arch Surg. 1986 Jun;121(6):649-53. doi: 10.1001/archsurg.1986.01400060043004.
A retrospective study was undertaken to examine the incidence and clinical significance of enterococcal bacteremia in burned patients with enterococcal burn-wound infections. During a 26-month period from 1983 to 1985, 38 patients were found to have enterococcal burn-wound infections. Twenty of these patients developed positive blood cultures for enterococcus with no other identifiable source for the bacteremia. Cases occurred sporadically during the study period without evidence of a specific epidemic. Ten patients died within ten days of the bacteremia, while nine others eventually died from other complications. Only one patient survived to discharge. Prior antibiotic therapy did not appear to increase the risk for enterococcal infection, and specific therapy against the enterococcus after the bacteremia was identified appeared to have no effect on mortality. Mortality was significantly greater for bacteremic patients than for patients with enterococcal wound infection alone or for burned patients without enterococcal infections. Although previously not considered pathogenic, enterococcal burn-wound infections should prompt aggressive therapy to prevent the development of enterococcal sepsis with its associated high mortality.
进行了一项回顾性研究，以检查患有肠球菌烧伤创面感染的烧伤患者中肠球菌血症的发生率及其临床意义。在1983年至1985年的26个月期间，发现38例患者患有肠球菌烧伤创面感染。其中20例患者血培养肠球菌呈阳性，且无其他可识别的菌血症来源。在研究期间病例呈散发性出现，无特定流行的证据。10例患者在菌血症发生后10天内死亡，另外9例最终死于其他并发症。只有1例患者存活至出院。先前的抗生素治疗似乎并未增加肠球菌感染的风险，在确定菌血症后针对肠球菌的特异性治疗似乎对死亡率没有影响。菌血症患者的死亡率显著高于仅患有肠球菌创面感染的患者或没有肠球菌感染的烧伤患者。尽管肠球菌以前不被认为具有致病性，但肠球菌烧伤创面感染应促使进行积极治疗，以预防肠球菌败血症的发生及其相关的高死亡率。
