Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Clinic of Rheumatology, Department of Medical and Biological Sciences, University Hospital Santa Maria della Misericordia, Udine, Italy.
Clin Exp Rheumatol. 2023 Apr;41(4):765-773. doi: 10.55563/clinexprheumatol/zf4daj. Epub 2023 Apr 18.
Systemic vasculitides are heterogeneous disabling diseases characterised by chronic inflammation of the blood vessels potentially leading to tissue destruction and organ failure. The recent COVID-19 pandemic has had a significant impact on the epidemiology and management of patients with systemic vasculitis. In parallel, new insights have been provided on systemic vasculitis pathogenetic mechanisms, possible new therapeutic targets, and newer glucocorticoid-sparing treatments with better safety profiles. As in the previous annual reviews of this series, in this review we will provide a critical digest of the most recent literature regarding pathophysiology, clinical manifestations, diagnostic tools and treatment options in small- and large-vessel vasculitis focusing on precision medicine in vasculitis.
系统性血管炎是一组异质性、致残性疾病，其特征为血管慢性炎症，可能导致组织破坏和器官衰竭。最近的 COVID-19 大流行对系统性血管炎患者的流行病学和治疗产生了重大影响。与此同时，人们对系统性血管炎发病机制、可能的新治疗靶点以及具有更好安全性的新型糖皮质激素节约治疗方法有了新的认识。与本系列之前的年度综述一样，在本次综述中，我们将重点关注血管炎的精准医学，批判性地总结小血管和大血管血管炎的病理生理学、临床表现、诊断工具和治疗选择方面的最新文献。
