Radiology, Yantai Affiliated Hospital of Binzhou Medical University.
Pathology, Yantai Affiliated Hospital of Binzhou Medical University.
Rev Esp Enferm Dig. 2024 Jan;116(1):48-49. doi: 10.17235/reed.2023.9624/2023.
A 58-year-old woman presented with a 1-day history of abdominal pain. Abdominal CT showed an oval soft tissue density mass in the fundus of the gallbladder (red arrow), approximately 4.0 cm × 3.0 cm in size. The level of cancer antigen 199 was elevated (275.80 U/mL; normal level, 0.0-27.0 U/mL). Other tumor markers were normal including alpha fetoprotein, carcinoembryonic antigen. Abdominal magnetic resonance imaging demonstrated the mass with characteristic of mixed signals, containing marked enhanced ingredient (yellow arrow) and poor blood supply ingredient (blue arrow). Radical cholecystectomy, partial liver resection, and regional lymphadenectomy were performed. Pathological examination indicated mixed adenoneuroendocrine carcinoma, with the following immunohistochemistry results: CD56 (+) (Figure 1F), Syn (+) (Figure 1G), CK19 (+) (Figure 1H), CgA (+), MLHL (+), PMS2 (+), MSH2 (+), MSH6 (+), Ki-67 (60%+).
一位 58 岁女性因腹痛 1 天就诊。腹部 CT 显示胆囊底部有一椭圆形软组织密度肿块（红色箭头），大小约 4.0cm×3.0cm。癌抗原 199 水平升高（275.80 U/mL；正常值 0.0-27.0 U/mL）。其他肿瘤标志物正常，包括甲胎蛋白、癌胚抗原。腹部磁共振成像显示肿块具有混合信号特征，包含明显增强成分（黄色箭头）和血供不良成分（蓝色箭头）。行根治性胆囊切除术、部分肝切除术和区域淋巴结清扫术。病理检查提示混合性腺神经内分泌癌，免疫组化结果如下：CD56（+）（图 1F），Syn（+）（图 1G），CK19（+）（图 1H），CgA（+），MLHL（+），PMS2（+），MSH2（+），MSH6（+），Ki-67（60%+）。
