Serov V V
Arkh Patol. 1986;48(3):20-9.
New approaches and possibilities of studying such categories in general pathology as morphogenesis, pathogenesis and nozology are considered. The study of morphogenesis is shown to be the most perspective in the analysis of functioning of the systems responsible for the specialized function of a given structure; cell regulatory systems (cell cooperations); antagonistic functions at different structural levels. Pathogenesis, as a category of general pathology, can be studied most efficiently by the pathologist when investigating the responsiveness (cell defence systems, neuro-endocrine and local cell regulation, heredity). A role of the pathologist determining nozology is most efficient in the search of etiological, pathogenetic and organospecific (for tumours) markers. The prospects and methodological significance of such investigations are pointed out.
本文探讨了在普通病理学中研究形态发生、发病机制和疾病分类学等范畴的新方法和可能性。研究表明,形态发生的研究在分析负责特定结构特殊功能的系统功能方面最具前景;细胞调节系统(细胞合作);不同结构水平的拮抗功能。发病机制作为普通病理学的一个范畴,病理学家在研究反应性(细胞防御系统、神经内分泌和局部细胞调节、遗传)时能最有效地进行研究。病理学家在确定疾病分类学方面的作用在寻找病因、发病机制和器官特异性(针对肿瘤)标志物方面最为有效。文中指出了此类研究的前景和方法学意义。