School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
Crit Rev Microbiol. 2024 May;50(3):371-384. doi: 10.1080/1040841X.2023.2202237. Epub 2023 Apr 19.
Live biotherapeutic product (LBP), a type of biological product, holds promise for the prevention or treatment of metabolic disease and pathogenic infection. Probiotics are live microorganisms that improve the intestinal microbial balance and beneficially affect the health of the host when ingested in sufficient numbers. These biological products possess the advantages of inhibition of pathogens, degradation of toxins, and modulation of immunity. The application of LBP and probiotic delivery systems has attracted great interest to researchers. The initial used technologies for LBP and probiotic encapsulation are traditional capsules and microcapsules. However, the stability and targeted delivery capability require further improved. The specific sensitive materials can greatly improve the delivery efficiency of LBPs and probiotics. The specific sensitive delivery systems show advantages over traditional ones due to their better properties of biocompatibility, biodegradability, innocuousness, and stability. Moreover, some new technologies, including layer-by-layer encapsulation, polyelectrolyte complexation, and electrohydrodynamic technology, show great potential in LBP and probiotic delivery. In this review, novel delivery systems and new technologies of LBPs and probiotics were presented, and the challenges and prospects were explored in specific sensitive materials for LBP and probiotic delivery.
活菌治疗产品（LBP）是一种生物制品，有望预防或治疗代谢疾病和病原感染。益生菌是活的微生物，当以足够数量摄入时，可改善肠道微生物平衡并对宿主健康产生有益影响。这些生物制品具有抑制病原体、降解毒素和调节免疫的优势。LBP 和益生菌输送系统的应用引起了研究人员的极大兴趣。最初用于 LBP 和益生菌包封的技术是传统的胶囊和微胶囊。然而，其稳定性和靶向输送能力需要进一步提高。特定敏感材料可以大大提高 LBPs 和益生菌的输送效率。特定敏感的输送系统具有优于传统系统的优势，因为它们具有更好的生物相容性、生物降解性、无害性和稳定性。此外，一些新技术，包括层层包裹、聚电解质复合和电动力学技术，在 LBP 和益生菌输送方面显示出巨大的潜力。本文综述了 LBP 和益生菌的新型输送系统和新技术，并探讨了 LBP 和益生菌输送用特定敏感材料的挑战和前景。
