Ribarov S, Benov L, Benchev I
Biomed Biochim Acta. 1986;45(3):321-30.
In order to elucidate the possible mechanism of initiation of lipid peroxidation in AgNO3-treated erythrocytes, the effect of AgNO3 on hemoglobin-catalyzed peroxidation of phospholipid liposomes was studied. It was found that Ag+ significantly increases the rate of hemoglobin-catalyzed peroxidation. The inhibition of this effect by superoxide dismutase and catalase suggests that superoxide radical and H2O2 are involved. It was demonstrated also that Ag+ potentiates the hemoglobin autoxidation and increases the binding of hemoglobin to the erythrocyte membrane. On the basis of these findings a possible mechanism of initiation of peroxidation in AgNO3-treated erythrocytes is discussed.
为了阐明硝酸银处理的红细胞中脂质过氧化启动的可能机制，研究了硝酸银对血红蛋白催化的磷脂脂质体过氧化的影响。发现银离子显著提高了血红蛋白催化的过氧化速率。超氧化物歧化酶和过氧化氢酶对这种效应的抑制表明超氧阴离子自由基和过氧化氢参与其中。还证明银离子增强了血红蛋白的自氧化，并增加了血红蛋白与红细胞膜的结合。基于这些发现，讨论了硝酸银处理的红细胞中过氧化启动的可能机制。
