Gramatté T, Schmidt J
Biomed Biochim Acta. 1986;45(4):523-9.
Rats exposed to an intermittent long-term hypoxia in the early postnatal life show a marked hyperactivity in the open field test at day 15 and 38 of life. This effect disappears during maturity. The spontaneous nocturnal activity of adult animals oxygen deprived postnatally was found to be elevated. These results may be a possible consequence of the hypoxic injury during the growth spurt period of neuronal systems which play an important role in the control of locomotor behaviour. The method used and the results obtained seem to meet some requirements of an animal model for symptoms associated with the syndrome referred to as "Minimal Brain Dysfunction".
在出生后早期生活中暴露于间歇性长期缺氧的大鼠，在出生后第15天和第38天的旷场试验中表现出明显的多动。这种效应在成熟过程中消失。发现出生后缺氧的成年动物的夜间自发活动有所增加。这些结果可能是神经元系统生长突增期缺氧损伤的一个可能后果，而神经元系统在运动行为控制中起重要作用。所使用的方法和获得的结果似乎符合一种动物模型的某些要求，该模型用于研究与“轻微脑功能障碍”综合征相关的症状。
