Laboratoire de Neurosciences Cognitives et Adaptives (LNCA), UMR 7364 CNRS - Université de Strasbourg (UNISTRA), 12 rue Goethe, 67000 Strasbourg, France.
Laboratoire de Neurosciences Cognitives et Adaptives (LNCA), UMR 7364 CNRS - Université de Strasbourg (UNISTRA), 12 rue Goethe, 67000 Strasbourg, France.
Clin Neurophysiol. 2023 Jun;150:184-193. doi: 10.1016/j.clinph.2023.03.014. Epub 2023 Apr 4.
We aimed to determine the ability of an innovative device, the Cutaneous Mechanical Stimulator (CMS), to evaluate touch sensory pathways in Human.
Two experiments were conducted in 23 healthy volunteers aged 20-30 years. In the first, mechanical detection thresholds (MDTs) were assessed using Semmes-Weinstein monofilaments and the CMS. In the second experiment, touch-evoked potentials (TEPs) elicited by tactile stimulation of the CMS on the left hand dorsum and left foot dorsum were recorded. Electroencephalographic (EEG) data were recorded at each cutaneous stimulation site in blocks of 20 tactile stimulations delivered by the CMS. The data were segmented into 1000-ms epochs.
MDTs measured by monofilaments and by the CMS were equivalent. Analyses of TEPs showed N2 and P2 components. The latencies of the N2 components on the hand dorsum and foot dorsum resulted in an estimated average conduction velocity of about 40 m.s, within the range of Aβ fibers.
These findings showed that the CMS could assess touch sensory pathways in young adults.
The CMS can offer new research perspectives, as this device allows easy assessment of the MDT and enables estimation of fiber conduction velocities after tactile stimulation by the device synchronized with EEG recordings.
我们旨在确定一种创新设备，即皮肤机械刺激器（CMS），在评估人类触觉感知通路方面的能力。
本研究共纳入了 23 名年龄在 20-30 岁的健康志愿者，进行了两项实验。在第一项实验中，使用 Semmes-Weinstein 单丝和 CMS 评估机械检测阈值（MDTs）。在第二项实验中，记录了通过 CMS 在手背和脚背的触觉刺激引起的触觉诱发电位（TEPs）。在每个皮肤刺激部位以 CMS 施加的 20 次触觉刺激的块进行记录。EEG 数据在 1000-ms 时窗中被分段。
用单丝和 CMS 测量的 MDTs 相当。TEP 分析显示出 N2 和 P2 成分。在手背和脚背的 N2 成分的潜伏期导致大约 40 m.s 的平均传导速度的估计，在 Aβ 纤维的范围内。
这些发现表明，CMS 可以评估年轻人的触觉感知通路。
CMS 可以提供新的研究视角，因为该设备可以轻松评估 MDT，并在与 EEG 记录同步的设备触觉刺激后估计纤维传导速度。
