利用 NF1 缺失的乳腺癌中的代谢脆弱性。
Exploiting metabolic vulnerabilities in breast cancers with NF1 loss.
机构信息
Division of Medical Oncology, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583; Oncology Academic Clinical Programme, Duke-NUS Medical School, 8 College Road, Singapore 169857.
The Division of Cellular and Molecular Research, National Cancer Centre Singapore, 30 Hospital Boulevard, Singapore 168583; The Cancer and Stem Cell Program, Duke-NUS Medical School, 8 College Road, Singapore 169857.
出版信息
Cell Rep Med. 2023 Apr 18;4(4):101010. doi: 10.1016/j.xcrm.2023.101010.
Auf der Maur et al. identify neurofibromin 1 (NF1) loss as a mechanism of resistance to PI3K inhibitor in breast cancer cells. NF1 loss leads to enhanced glycolysis, which may be targeted with the antioxidant N-acetyl cysteine (NAC).
奥夫·毛尔等人发现神经纤维瘤蛋白 1（NF1）缺失是乳腺癌细胞对 PI3K 抑制剂产生耐药性的一种机制。NF1 的缺失导致糖酵解增强，而抗氧化剂 N-乙酰半胱氨酸（NAC）可能成为其靶向治疗药物。
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