Physical Education Department, Xi'an University of Finance and Economics, 64 Xiaozhai E Rd, Yanta District, Xi'An, Shaanxi, China.
Physical Education Department, Renmin University of China, No. 59, Zhongguancun Street, Haidian District, Beijing, China.
Environ Res. 2023 Jul 15;229:115781. doi: 10.1016/j.envres.2023.115781. Epub 2023 Apr 17.
Endocrine disrupting chemicals (EDCs) have been extensively explored due to their harmful effects on individual health and the environment by interfering with hormone activity and disrupting the endocrine system. However, their relationship with essential trace elements remains uncertain. This research aimed to investigate the possible correlation between essential trace elements and toxic metals, including cadmium (Cd), and lead (Pb) in children aged 1-5 years with various infectious diseases, including gastrointestinal disorders, typhoid fever, and pneumonia. The study was conducted on biological testing and specimen (scalp hair and whole blood) of diseased and non-diseased children of the same residential area and referent/control age-matched children from developed cities consuming domestically treated water. The media of biological samples were oxidized by an acid mixture before being analyzed by atomic absorption spectrophotometry. The accuracy and validity of the methodology were verified through accredited reference material from scalp hair and whole blood sample. The study results revealed that diseased children had lower mean values of essential trace elements (iron, copper, and zinc) in both scalp hair and blood, except for copper, which was found to be higher in blood samples of diseased children. This implies that the deficiency of essential residue and trace elements in children from rural areas who consume groundwater is linked to various infectious diseases. The study highlights the need for more human biomonitoring of EDCs to better comprehend their non-classical toxic properties and their concealed costs on human health. The findings suggest that exposure to EDCs could be associated with unfavorable health outcomes and emphasizes the need for future regulatory policies to minimize exposure and safeguard the health of current and forthcoming generations of children. Furthermore, the study highlights the implication of essential trace elements in maintaining good health and their potential correlation with toxic metals in the environment.
内分泌干扰化学物质（EDCs）因其对个体健康和环境的有害影响而被广泛研究，这些影响是通过干扰激素活性和破坏内分泌系统而产生的。然而，它们与必需微量元素之间的关系尚不确定。本研究旨在调查必需微量元素与有毒金属（包括镉（Cd）和铅（Pb））之间的可能相关性，这些金属存在于患有各种传染病（包括胃肠道疾病、伤寒和肺炎）的 1-5 岁儿童中。该研究对来自同一居住地区的患病和非患病儿童以及来自发达城市、饮用国内处理水的同年龄参照/对照儿童的生物测试和标本（头皮头发和全血）进行了检测。在对生物样本进行原子吸收分光光度法分析之前，先用酸混合物对其进行氧化。通过来自头皮头发和全血样本的经过认证的参考物质，验证了方法的准确性和有效性。研究结果表明，患病儿童的头皮头发和血液中的必需微量元素（铁、铜和锌）的平均值均较低，除了铜，患病儿童的血液中铜含量较高。这意味着，农村地区儿童因饮用地下水而导致必需微量元素和痕量元素的缺乏，与各种传染病有关。该研究强调了需要对内分泌干扰物进行更多的人体生物监测，以更好地理解其非经典毒性特性及其对人类健康的隐蔽成本。研究结果表明，接触内分泌干扰物可能与不良健康结果有关，并强调需要制定未来的监管政策，以减少接触并保护当前和未来几代儿童的健康。此外，该研究还强调了必需微量元素在维持良好健康方面的重要性，以及它们与环境中毒金属之间的潜在相关性。
