哮喘气道平滑肌细胞中的非编码 RNA。
Noncoding RNAs in asthmatic airway smooth muscle cells.
机构信息
Laboratory of Respiratory Disease, Affiliated Hospital of Guilin Medical University, Guilin, China.
Key Laboratory of Respiratory Diseases, Education Department of Guangxi Zhuang Autonomous Region, Guilin, China.
出版信息
Eur Respir Rev. 2023 Apr 19;32(168). doi: 10.1183/16000617.0184-2022. Print 2023 Jun 30.
Asthma is a complex and heterogeneous airway disease caused by genetic, environmental and epigenetic factors treated with hormones and biologics. Irreversible pathological changes to airway smooth muscle cells (ASMCs) such as hyperplasia and hypertrophy can occur in asthmatic patients. Determining the mechanisms responsible is vital for preventing such changes. In recent years, noncoding RNAs (ncRNAs), especially microRNAs, long noncoding RNAs and circular RNAs, have been found to be associated with abnormalities of the ASMCs. This review highlights recent ncRNA research into ASMC pathologies. We present a schematic that illustrates the role of ncRNAs in pathophysiological changes to ASMCs that may be useful in future research in diagnostic and treatment strategies for patients with asthma.
哮喘是一种由遗传、环境和表观遗传因素引起的复杂异质性气道疾病，采用激素和生物制剂进行治疗。哮喘患者的气道平滑肌细胞（ASMC）可能会发生不可逆的病理性改变，如增生和肥大。确定相关机制对于预防这些变化至关重要。近年来，非编码 RNA（ncRNA），特别是 microRNA、长非编码 RNA 和环状 RNA，与 ASMC 的异常相关。本综述强调了 ncRNA 对 ASMC 病理的最新研究。我们提出了一个示意图，说明了 ncRNA 在 ASMC 病理生理变化中的作用，这可能对未来哮喘患者的诊断和治疗策略的研究有用。
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