Marchetti G, Merlo L
Arzneimittelforschung. 1986 Feb;36(2A):331-3.
The activity of ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine, on myocardial contractility and systemic and renal hemodynamics was investigated in the anesthetized dog with experimental infarction, instrumented with catheters and electromagnetic flowmeters. Ibopamine, given by the intraduodenal route at a dose of 24 mg/kg, was effective in improving the hemodynamic parameters depressed by myocardial infarction, in particular myocardial contractility and renal hemodynamics. In eliciting such activity which resembles that developed by dopamine in similar experimental conditions, ibopamine seems to meet the requirements of an orally active pharmacological agent useful in the therapy of acute heart failure.
对 N-甲基多巴胺的 3,4-二异丁酰酯——异波帕明（SB-7505）在心肌梗死的麻醉犬身上对心肌收缩力以及全身和肾脏血流动力学的作用进行了研究。该犬通过导管和电磁流量计进行监测。以 24mg/kg 的剂量经十二指肠给予异波帕明，其可有效改善因心肌梗死而降低的血流动力学参数，尤其是心肌收缩力和肾脏血流动力学。在引发这种类似于多巴胺在类似实验条件下所产生的活性方面，异波帕明似乎符合一种可用于治疗急性心力衰竭的口服活性药物的要求。
