涂片阴性肺结核患者淋巴细胞亚群的变化
Changes of lymphocyte subsets in smear-negative pulmonary tuberculosis.
作者信息
Yang Xue, Feng Hao
机构信息
Infectious Diseases Section, Nanjing Jiangbei Hospital, Nanjing, China.
Infectious Diseases Section, Nanjing Jiangbei Hospital; Infectious Diseases Section, Nanjing Pukou Central Hospital, Pukou Branch Hospital of Jiangsu Province Hospital, Nanjing, China.
出版信息
Indian J Pathol Microbiol. 2023 Apr-Jun;66(2):321-326. doi: 10.4103/ijpm.ijpm_72_21.
BACKGROUND AND AIMS
The host immune system plays an important role in the pathogenesis and defense mechanism of Mycobacterium tuberculosis (Mtb). This study aimed to explore the different changes in the immune system between smear-negative pulmonary tuberculosis (PTB) and smear-positive PTB patients.
MATERIALS AND METHODS
A total of 85 active PTB patients and 50 healthy adults were enrolled. The participants were divided into smear-negative PTB, smear-positive PTB, and control groups. Chest computed tomography (CT) and lymphocyte subgroup counts in peripheral blood were measured in all participants.
RESULTS
There were higher numbers of CD4 + T-cells, NK cells, and pulmonary cavities in the smear-positive PTB group, whereas the numbers of B-ells were significantly increased in the smear-negative PTB group.
CONCLUSIONS
Smear-negative PTB showed fewer pulmonary cavities, mild inflammatory response, lower numbers of immune cells, and higher numbers of B- cells.
背景与目的
宿主免疫系统在结核分枝杆菌（Mtb）的发病机制和防御机制中发挥着重要作用。本研究旨在探讨涂片阴性肺结核（PTB）患者和涂片阳性PTB患者免疫系统的不同变化。
材料与方法
共纳入85例活动性PTB患者和50例健康成年人。参与者被分为涂片阴性PTB组、涂片阳性PTB组和对照组。对所有参与者进行胸部计算机断层扫描（CT）和外周血淋巴细胞亚群计数。
结果
涂片阳性PTB组的CD4 + T细胞、NK细胞数量及肺空洞数量较多，而涂片阴性PTB组的B细胞数量显著增加。
结论
涂片阴性PTB表现为肺空洞较少、炎症反应较轻、免疫细胞数量较低以及B细胞数量较高。
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