Gene Polymorphisms Increase the Susceptibility to Tuberculosis.

PURPOSE

Tuberculosis (TB) is known to result from a complex interaction between the host immune response and infection. The transporter associated with antigen processing (TAP) plays an important role in the processing and presentation pathways for the () antigen. To investigate the possible association of the and genes with TB.

PATIENTS AND METHODS

A total of 449 TB patients and 435 control subjects were included in this study, and single nucleotide polymorphisms (SNPs) in the gene, as well as and alleles, were genotyped.

RESULTS

gene association analysis of TB diseases showed that rs41551515-T in the gene was significantly associated with susceptibility to TB (=7.96E-04, OR=4.124, 95% CI: 1.683-10.102), especially pulmonary TB (PTB, =6.84E-04, OR=4.350, 95% CI: 1.727-10.945), and the combination of rs1057141-T-rs1135216-C in the gene significantly increased the risk of TB susceptibility (=5.51E-05, OR=10.899, 95% CI: 2.555-46.493). Five novel alleles were detected in Yunnan Han people, and the allele frequency of (rs41555220-rs41549617-rs1057141-rs1135216-rs1057149-rs41551515: C-A-T-C-C-T) was notably increased in all TB patients, including in the PTB and EPTB subgroups, and was significantly associated with the risk of susceptibility to TB. However, no association between the gene and TB was found in this study.

CONCLUSION

Host genetic variants of rs41551515-T and the combination rs1057141-T-rs1135216-C, as well as may play a critical role in susceptibility to TB disease.