连合齿状颗粒细胞投射及其在成体大脑中的快速形成。
Commissural dentate granule cell projections and their rapid formation in the adult brain.
作者信息
Egger Matteo, Luo Wenshu, Cruz-Ochoa Natalia, Lukacsovich David, Varga Csaba, Que Lin, Maloveczky Gyula, Winterer Jochen, Kaur Rashmit, Lukacsovich Tamás, Földy Csaba
机构信息
Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
Adaptive Brain Circuits in Development and Learning (AdaBD), University Research Priority Program (URPP), University of Zürich, Zürich 8057, Switzerland.
出版信息
PNAS Nexus. 2023 Mar 20;2(4):pgad088. doi: 10.1093/pnasnexus/pgad088. eCollection 2023 Apr.
Dentate granule cells (GCs) have been characterized as unilaterally projecting neurons within each hippocampus. Here, we describe a unique class, the commissural GCs, which atypically project to the contralateral hippocampus in mice. Although commissural GCs are rare in the healthy brain, their number and contralateral axon density rapidly increase in a rodent model of temporal lobe epilepsies. In this model, commissural GC axon growth appears together with the well-studied hippocampal mossy fiber sprouting and may be important for the pathomechanisms of epilepsy. Our results augment the current view on hippocampal GC diversity and demonstrate powerful activation of a commissural wiring program in the adult brain.
齿状颗粒细胞（GCs）已被表征为每个海马体内单侧投射的神经元。在此，我们描述了一类独特的细胞，即连合GCs，它们在小鼠中异常地投射到对侧海马体。尽管连合GCs在健康大脑中很少见，但在颞叶癫痫的啮齿动物模型中，它们的数量和对侧轴突密度会迅速增加。在这个模型中，连合GC轴突生长与已被充分研究的海马苔藓纤维发芽同时出现，并且可能对癫痫的发病机制很重要。我们的结果扩展了目前关于海马GC多样性的观点，并证明了成年大脑中连合布线程序的强大激活。
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