Giles W B, Trudinger B J
Br J Obstet Gynaecol. 1986 May;93(5):466-70.
The possibility was examined of an association between umbilical cord whole blood viscosity and umbilical artery flow velocity time waveforms obtained with continuous wave Doppler ultrasound. The cord blood viscosity was measured at both high (100 s-1) and low (0.1 s-1) shear rates with a concentric cylinder viscometer. Plasma viscosity and fibrinogen were also measured. An abnormal pattern in the umbilical artery flow velocity waveform (high A/B ratio) indicative of high resistance was associated with an increase in whole blood viscosity at high shear (which may reflect a change in red cell rigidity). Viscosity at low shear (reflecting red cell aggregation and rouleaux formation) did not differ. There was a significant association between the small-for-gestational age fetus and abnormal umbilical artery waveform study (P less than 0.002) but not abnormal whole blood viscosity at high (P = 0.09) or low (P = 0.08) shear.
研究了脐带全血粘度与通过连续波多普勒超声获得的脐动脉血流速度时间波形之间关联的可能性。使用同心圆筒粘度计在高剪切率（100 s-1）和低剪切率（0.1 s-1）下测量脐带血粘度。还测量了血浆粘度和纤维蛋白原。脐动脉血流速度波形的异常模式（高A/B比）表明阻力增加，与高剪切时全血粘度增加相关（这可能反映红细胞刚性的变化）。低剪切时的粘度（反映红细胞聚集和缗钱状形成）无差异。小于胎龄儿与异常脐动脉波形研究之间存在显著关联（P小于0.002），但与高剪切（P = 0.09）或低剪切（P = 0.08）时的异常全血粘度无关。
