Gupta Shreya, Yapp Liam Z, Sadczuk Dominika, MacDonald Deborah J, Clement Nick D, White Tim O, Keating John F, Scott Chloe E H
Department of Orthopaedics, The University of Edinburgh, Edinburgh, UK.
Edinburgh Orthopaedic Trauma Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
Bone Jt Open. 2023 Apr 20;4(4):273-282. doi: 10.1302/2633-1462.44.BJO-2023-0022.R1.
To investigate health-related quality of life (HRQoL) of older adults (aged ≥ 60 years) after tibial plateau fracture (TPF) compared to preinjury and population matched values, and what aspects of treatment were most important to patients. We undertook a retrospective, case-control study of 67 patients at mean 3.5 years (SD 1.3; 1.3 to 6.1) after TPF (47 patients underwent fixation, and 20 nonoperative management). Patients completed EuroQol five-dimension three-level (EQ-5D-3L) questionnaire, Lower Limb Function Scale (LEFS), and Oxford Knee Scores (OKS) for current and recalled prefracture status. Propensity score matching for age, sex, and deprivation in a 1:5 ratio was performed using patient level data from the Health Survey for England to obtain a control group for HRQoL comparison. The primary outcome was the difference in actual (TPF cohort) and expected (matched control) EQ-5D-3L score after TPF. TPF patients had a significantly worse EQ-5D-3L utility (mean difference (MD) 0.09, 95% confidence interval (CI) 0.00 to 0.16; p < 0.001) following their injury compared to matched controls, and had a significant deterioration (MD 0.140, 95% CI 0 to 0.309; p < 0.001) relative to their preoperative status. TPF patients had significantly greater pre-fracture EQ-5D-3L scores compared to controls (p = 0.003), specifically in mobility and pain/discomfort domains. A decline in EQ-5D-3L greater than the minimal important change of 0.105 was present in 36/67 TPF patients (53.7%). Following TPF, OKS (MD -7; interquartile range (IQR) -1 to -15) and LEFS (MD -10; IQR -2 to -26) declined significantly (p < 0.001) from pre-fracture levels. Of the 12 elements of fracture care assessed, the most important to patients were getting back to their own home, having a stable knee, and returning to normal function. TPFs in older adults were associated with a clinically significant deterioration in HRQoL compared to preinjury level and age, sex, and deprivation matched controls for both undisplaced fractures managed nonoperatively and displaced or unstable fractures managed with internal fixation.
为了比较胫骨平台骨折(TPF)后老年患者(年龄≥60岁)与受伤前及年龄匹配人群的健康相关生活质量(HRQoL),并探究治疗的哪些方面对患者最为重要。我们进行了一项回顾性病例对照研究,纳入了67例TPF后平均3.5年(标准差1.3;1.3至6.1年)的患者(47例接受内固定,20例接受非手术治疗)。患者完成了欧洲五维健康量表(EQ-5D-3L)问卷、下肢功能量表(LEFS)以及牛津膝关节评分(OKS),以评估当前和回忆起的骨折前状态。利用来自英格兰健康调查的患者层面数据,按1:5的比例对年龄、性别和贫困程度进行倾向得分匹配,以获得用于HRQoL比较的对照组。主要结局指标是TPF后实际(TPF队列)和预期(匹配对照组)EQ-5D-3L评分的差异。与匹配对照组相比,TPF患者受伤后的EQ-5D-3L效用显著更差(平均差异(MD)0.09,95%置信区间(CI)0.00至0.16;p<0.001),并且相对于术前状态有显著恶化(MD 0.140,95%CI 0至0.309;p<0.001)。与对照组相比,TPF患者骨折前的EQ-5D-3L评分显著更高(p = 0.003),特别是在活动能力和疼痛/不适领域。在67例TPF患者中有36例(53.7%)的EQ-5D-3L下降幅度大于最小重要变化值0.105。TPF后,OKS(MD -7;四分位数间距(IQR)-1至-15)和LEFS(MD -10;IQR -2至-26)较骨折前水平显著下降(p<0.001)。在评估的12项骨折护理要素中,对患者最重要的是回到自己家中、膝关节稳定以及恢复正常功能。与受伤前水平以及年龄、性别和贫困程度匹配的对照组相比,老年患者的TPF无论是非手术治疗的无移位骨折还是内固定治疗的移位或不稳定骨折,均与HRQoL的临床显著恶化相关。