Yapp Liam Z, Scott Chloe E H, Howie Colin R, MacDonald Deborah J, Simpson A Hamish R W, Clement Nick D
Department of Orthopaedics, Division of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, UK.
Department of Trauma & Orthopaedic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK.
Bone Joint Res. 2022 Sep;11(9):619-628. doi: 10.1302/2046-3758.119.BJR-2022-0054.R1.
The aim of this study was to report the meaningful values of the EuroQol five-dimension three-level questionnaire (EQ-5D-3L) and EuroQol visual analogue scale (EQ-VAS) in patients undergoing primary knee arthroplasty (KA).
This is a retrospective study of patients undergoing primary KA for osteoarthritis in a university teaching hospital (Royal Infirmary of Edinburgh) (1 January 2013 to 31 December 2019). Pre- and postoperative (one-year) data were prospectively collected for 3,181 patients (median age 69.9 years (interquartile range (IQR) 64.2 to 76.1); females, n = 1,745 (54.9%); median BMI 30.1 kg/m (IQR 26.6 to 34.2)). The reliability of the EQ-5D-3L was measured using Cronbach's alpha. Responsiveness was determined by calculating the anchor-based minimal clinically important difference (MCID), the minimal important change (MIC) (cohort and individual), the patient-acceptable symptom state (PASS) predictive of satisfaction, and the minimal detectable change at 90% confidence intervals (MDC-90).
The EQ-5D-3L demonstrated good internal consistency with an overall Cronbach alpha of 0.75 (preoperative) and 0.88 (postoperative), respectively. The MCID for the Index score was 0.085 (95% confidence interval (CI) 0.042 to 0.127) and EQ-VAS was 6.41 (95% CI 3.497 to 9.323). The MIC was 0.289 for the EQ-5D and 5.27 for the EQ-VAS. However, the MIC for both the EQ-5D-3L Index (0.105) and EQ-VAS (-1) demonstrated poor-to-acceptable reliability. The MDC-90 was 0.023 for the EQ-5D-3L Index and 1.0 for the EQ-VAS. The PASS for the postoperative EQ-5D-3L Index and EQ-VAS scores predictive of patient satisfaction were 0.708 and 77.0, respectively.
The meaningful values of the EQ-5D-3L Index and EQ-VAS scores can be used to measure clinically relevant changes in health-related quality of life in patients undergoing primary KA.Cite this article: 2022;11(9):619-628.
本研究旨在报告欧洲五维健康量表（EQ-5D-3L）和欧洲视觉模拟量表（EQ-VAS）在初次膝关节置换术（KA）患者中的有意义值。
这是一项对一家大学教学医院（爱丁堡皇家医院）2013年1月1日至2019年12月31日期间因骨关节炎接受初次KA手术患者的回顾性研究。前瞻性收集了3181例患者术前和术后（一年）的数据（中位年龄69.9岁（四分位间距（IQR）64.2至76.1）；女性，n = 1745例（54.9%）；中位体重指数30.1kg/m²（IQR 26.6至34.2））。使用Cronbach's alpha系数测量EQ-5D-3L的信度。通过计算基于锚定的最小临床重要差异（MCID）、最小重要变化（MIC）（队列和个体）、预测满意度的患者可接受症状状态（PASS）以及90%置信区间的最小可检测变化（MDC-90）来确定反应度。
EQ-5D-3L显示出良好的内部一致性，总体Cronbach's alpha系数术前为0.75，术后为0.88。指数得分的MCID为0.085（95%置信区间（CI）0.042至0.127），EQ-VAS为6.41（95%CI 3.497至9.323）。EQ-5D的MIC为0.289，EQ-VAS为5.27。然而，EQ-5D-3L指数（0.105）和EQ-VAS（-1）的MIC显示出从较差到可接受的信度。EQ-5D-3L指数的MDC-90为0.023，EQ-VAS为1.0。术后EQ-5D-3L指数和EQ-VAS得分预测患者满意度的PASS分别为0.708和77.0。
EQ-5D-3L指数和EQ-VAS得分的有意义值可用于测量初次KA患者健康相关生活质量的临床相关变化。引用本文：2022;11(9):619 - 628。
