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Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
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Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling.
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Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase.
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Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
Cell Res. 2023 Nov;33(11):835-850. doi: 10.1038/s41422-023-00874-4. Epub 2023 Sep 19.
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Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
J Exp Clin Cancer Res. 2019 Feb 11;38(1):66. doi: 10.1186/s13046-019-1053-y.
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Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.
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Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3.
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Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation.
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Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to promote a cancer stem cell phenotype in hepatocellular carcinoma.
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Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression.
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PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling.
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Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms.
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Functional Roles and Mechanistic Insights of YEATS Domain Proteins in Digestive System Tumors.
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Therapeutic potential of tumor-associated neutrophils: dual role and phenotypic plasticity.
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Metabolic reprogramming of tumor-associated neutrophils in tumor treatment and therapeutic resistance.
Front Cell Dev Biol. 2025 Apr 24;13:1584987. doi: 10.3389/fcell.2025.1584987. eCollection 2025.
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Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer's disease.
Cell. 2025 Jun 26;188(13):3513-3529.e26. doi: 10.1016/j.cell.2025.03.045. Epub 2025 Apr 23.
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Harnessing amino acid pathways to influence myeloid cell function in tumor immunity.
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SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer.
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The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress.
Nat Metab. 2021 Oct;3(10):1357-1371. doi: 10.1038/s42255-021-00456-x. Epub 2021 Oct 18.
2
The Transcriptional Coactivator, ALL1-Fused Gene From Chromosome 9, Simultaneously Sustains Hypoxia Tolerance and Metabolic Advantages in Liver Cancer.
Hepatology. 2021 Oct;74(4):1952-1970. doi: 10.1002/hep.31870. Epub 2021 Aug 10.
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Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.
Cancer Discov. 2020 Sep;10(9):1352-1373. doi: 10.1158/2159-8290.CD-19-1228. Epub 2020 Jun 22.
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Tumor-Associated Macrophages: Recent Insights and Therapies.
Front Oncol. 2020 Feb 25;10:188. doi: 10.3389/fonc.2020.00188. eCollection 2020.
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Tumor Microenvironment.
Medicina (Kaunas). 2019 Dec 30;56(1):15. doi: 10.3390/medicina56010015.
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Interleukin-22 Ameliorates Neutrophil-Driven Nonalcoholic Steatohepatitis Through Multiple Targets.
Hepatology. 2020 Aug;72(2):412-429. doi: 10.1002/hep.31031. Epub 2020 Mar 16.
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Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC.
Nat Commun. 2019 Oct 15;10(1):4681. doi: 10.1038/s41467-019-12606-7.
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Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma.
Cell. 2019 Oct 3;179(2):561-577.e22. doi: 10.1016/j.cell.2019.08.052.
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Interleukin-8 promotes cell migration via CXCR1 and CXCR2 in liver cancer.
Oncol Lett. 2019 Oct;18(4):4176-4184. doi: 10.3892/ol.2019.10735. Epub 2019 Aug 8.
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α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development.
Mol Cell. 2019 Oct 3;76(1):148-162.e7. doi: 10.1016/j.molcel.2019.07.007. Epub 2019 Aug 22.
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