Not so fast, antithrombin!
作者信息
Majumder Rinku
机构信息
LSU Health Sciences Center.
出版信息
Blood. 2023 Apr 20;141(16):1907-1908. doi: 10.1182/blood.2023019793.
Abstract
摘要
相似文献
1
Not so fast, antithrombin!没那么快，抗凝血酶！
Blood. 2023 Apr 20;141(16):1907-1908. doi: 10.1182/blood.2023019793.
2
Residues Tyr253 and Glu255 in strand 3 of beta-sheet C of antithrombin are key determinants of an exosite made accessible by heparin activation to promote rapid inhibition of factors Xa and IXa.抗凝血酶β-折叠C的第3条链中的酪氨酸253和谷氨酸255残基是一个外位点的关键决定因素，该外位点通过肝素激活变得可及，以促进对因子Xa和IXa的快速抑制。
J Biol Chem. 2006 May 12;281(19):13424-13432. doi: 10.1074/jbc.M600415200. Epub 2006 Mar 3.
3
Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites.肝素和钙离子通过产生新的相互作用外位点，显著增强抗凝血酶与因子IXa的反应性。
Biochemistry. 2003 Jul 15;42(27):8143-52. doi: 10.1021/bi034363y.
4
Novel oral anticoagulants. Part II: direct thrombin inhibitors.新型口服抗凝药物。第二部分：直接凝血酶抑制剂。
Expert Rev Hematol. 2010 Jun;3(3):351-61. doi: 10.1586/ehm.10.12.
5
Mechanism of catalysis of inhibition of factor IXa by antithrombin in the presence of heparin or pentasaccharide.在肝素或五糖存在的情况下抗凝血酶抑制因子IXa的催化机制。
J Biol Chem. 2003 Sep 12;278(37):35767-74. doi: 10.1074/jbc.M304803200. Epub 2003 Jun 27.
6
Inhibition of factor IXa and factor Xa by antithrombin III/heparin during factor X activation.在因子X激活过程中抗凝血酶III/肝素对因子IXa和因子Xa的抑制作用。
J Biol Chem. 1988 Oct 25;263(30):15313-8.
8
[On serum and heparin antithrombin].[关于血清和肝素抗凝血酶]
Postepy Hig Med Dosw. 1961 May-Jun;15:297-312.
9
Mechanism of factor IXa inhibition by antithrombin in the presence of unfractionated and low molecular weight heparins and fucoidan.在存在普通肝素、低分子量肝素和岩藻依聚糖的情况下，抗凝血酶对因子IXa的抑制机制。
Biochim Biophys Acta. 1998 Sep 8;1387(1-2):184-94. doi: 10.1016/s0167-4838(98)00120-4.
10
[A method for isolated determination of thrombin inhibitor and antithrombin].[一种用于单独测定凝血酶抑制剂和抗凝血酶的方法]
Klin Wochenschr. 1953 Jul 1;31(25-26):598-600. doi: 10.1007/BF01477809.
本文引用的文献
1
Factor IXa variants resistant to plasma inhibitors enhance clot formation in vivo.因子 IXa 变异体对血浆抑制剂的耐药性增强了体内血栓的形成。
Blood. 2023 Apr 20;141(16):2022-2032. doi: 10.1182/blood.2022018083.
2
Probing activation-driven changes in coagulation factor IX by mass spectrometry.利用质谱技术探测凝血因子 IX 的激活驱动变化。
J Thromb Haemost. 2021 Jun;19(6):1447-1459. doi: 10.1111/jth.15288. Epub 2021 Apr 5.
3
Activated protein C has a regulatory role in factor VIII function.活化蛋白 C 在因子 VIII 功能中具有调节作用。
Blood. 2021 May 6;137(18):2532-2543. doi: 10.1182/blood.2020007562.
4
Suppressing protein Z-dependent inhibition of factor Xa improves coagulation in hemophilia A.抑制蛋白 Z 依赖性的因子 Xa 抑制可改善血友病 A 的凝血功能。
J Thromb Haemost. 2019 Jan;17(1):149-156. doi: 10.1111/jth.14337. Epub 2018 Dec 16.
5
Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.抗凝蛋白 S 靶向因子 IXa 肝素结合外显子以预防血栓形成。
Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):816-828. doi: 10.1161/ATVBAHA.117.310588. Epub 2018 Feb 1.
6
Factor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa.VIIIa 因子 A2 亚基与因子 IXa 具有高亲和力相互作用：A2 亚基残基 707-714 对与因子 IXa 的相互作用的贡献。
J Biol Chem. 2013 May 24;288(21):15057-64. doi: 10.1074/jbc.M113.456467. Epub 2013 Apr 11.
7
Inhibition of intrinsic Xase by protein S: a novel regulatory role of protein S independent of activated protein C.蛋白 S 对内源性 X 因子的抑制作用：蛋白 S 独立于活化蛋白 C 的一种新的调节作用。
Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2387-93. doi: 10.1161/ATVBAHA.112.250928. Epub 2012 Aug 16.
8
Positive feedbacks of coagulation: their role in threshold regulation.
Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2463-9. doi: 10.1161/01.ATV.0000187463.91403.b2. Epub 2005 Sep 22.
9
Platelets and thrombin generation.血小板与凝血酶生成
Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1381-9. doi: 10.1161/01.atv.0000031340.68494.34.
10
Mechanism of factor IXa inhibition by antithrombin in the presence of unfractionated and low molecular weight heparins and fucoidan.在存在普通肝素、低分子量肝素和岩藻依聚糖的情况下，抗凝血酶对因子IXa的抑制机制。
Biochim Biophys Acta. 1998 Sep 8;1387(1-2):184-94. doi: 10.1016/s0167-4838(98)00120-4.
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