Shichijo S, Alving C R
Biochim Biophys Acta. 1986 Jun 13;858(1):118-24. doi: 10.1016/0005-2736(86)90297-x.
Specific immune damage to liposomes containing Forssman or globoside glycolipid was inhibited when the liposomes also contained ganglioside. The activity of a human monoclonal Waldenström macroglobulin antibody to Forssman glycolipid was inhibited by each of three gangliosides tested, GM3, GD1a and GD1b. Inhibition of the monoclonal antibody was dependent on the amount of ganglioside in the liposomes, and was diminished by reducing the relative amount of ganglioside. Inhibition also correlated positively with the number of ganglioside sialic acid groups, with inhibition by GT1b greater than GD1a greater than GM3. Naturally occurring human antibodies to globoside glycolipid were detected in 18% (9 out of 50) of normal human sera tested. Immune damage to liposomes induced by each of the three highest-reacting human anti-globoside sera was blocked by liposomal GM3. We conclude that gangliosides can strongly influence immune damage to membranes induced by antibody interactions with adjacent neutral glycolipids.
当脂质体中还含有神经节苷脂时，对含有福斯曼或球苷糖脂的脂质体的特异性免疫损伤受到抑制。所测试的三种神经节苷脂（GM3、GD1a和GD1b）中的每一种都能抑制人源单克隆瓦尔登斯特伦巨球蛋白抗体对福斯曼糖脂的活性。单克隆抗体的抑制作用取决于脂质体中神经节苷脂的含量，并且通过减少神经节苷脂的相对含量而减弱。抑制作用还与神经节苷脂唾液酸基团的数量呈正相关，GT1b的抑制作用大于GD1a大于GM3。在所测试的50份正常人血清中，有18%（9份）检测到天然存在的人抗球苷糖脂抗体。三种反应最强的人抗球苷血清中的每一种所诱导的脂质体免疫损伤都被脂质体GM3阻断。我们得出结论，神经节苷脂可强烈影响抗体与相邻中性糖脂相互作用所诱导的膜免疫损伤。
