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有医学用途和无医学用途大麻使用者的每日大麻使用与酒精使用之间的关联:替代还是互补?

Daily associations between cannabis use and alcohol use among people who use cannabis for both medicinal and nonmedicinal reasons: Substitution or complementarity?

机构信息

Department of Psychology, York University.

Bowles Center for Alcohol Studies, University of North Carolina-Chapel Hill.

出版信息

Psychol Addict Behav. 2023 Dec;37(8):1006-1018. doi: 10.1037/adb0000930. Epub 2023 Apr 20.

Abstract

OBJECTIVE

People who use cannabis for medicinal (vs. nonmedicinal) reasons report greater cannabis use and lower alcohol use, which may reflect a cannabis-alcohol substitution effect in this population. However, it is unclear whether cannabis is used as a substitute or complement to alcohol at the day level among people who use cannabis for medicinal and nonmedicinal reasons. This study used ecological momentary assessment to examine this question.

METHOD

Participants ( = 66; 53.1% men; mean age 33 years) completed daily surveys assessing previous-day reasons for cannabis use (medicinal vs. nonmedicinal), cannabis consumption (both number of different types of cannabis used and grams of cannabis flower used), and number of standard drinks consumed.

RESULTS

Multilevel models revealed that, in general, greater cannabis consumption on a given day was associated with greater same-day alcohol use. Further, days during which cannabis was used for medicinal (vs. exclusively nonmedicinal) reasons were associated with reduced consumption of cannabis and alcohol. The day-level association between medicinal reasons for cannabis use and lower alcohol consumption was mediated by using fewer grams of cannabis on medicinal cannabis use days.

CONCLUSIONS

Day-level cannabis-alcohol associations may be complementary rather than substitutive among people who use cannabis for both medicinal and nonmedicinal reasons, and lower (rather than greater) cannabis consumption on medicinal use days may explain the link between medicinal reasons for cannabis use and reduced alcohol use. Still, these individuals may use greater amounts of both cannabis and alcohol when using cannabis for exclusively nonmedicinal reasons. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

摘要

目的

出于医疗(而非非医疗)原因使用大麻的人报告称,他们使用大麻的频率更高,而饮酒频率更低,这可能反映出该人群中存在大麻-酒精替代效应。然而,尚不清楚在出于医疗和非医疗原因使用大麻的人群中,大麻是否在日水平上被用作酒精的替代品或补充品。本研究使用生态瞬时评估来检验这一问题。

方法

参与者(n=66;53.1%为男性;平均年龄 33 岁)完成了每日调查,评估前一天使用大麻的原因(医疗与非医疗)、大麻消费(使用的不同类型大麻的数量和使用的大麻花的克数)以及饮用的标准饮料数量。

结果

多层次模型显示,一般来说,在某一天内大麻使用量的增加与当天酒精使用量的增加有关。此外,大麻被用于医疗(而非纯粹非医疗)原因的日子与大麻和酒精消费的减少有关。使用大麻用于医疗目的与较低的酒精消费之间的日水平关联是通过在医疗大麻使用日减少使用的大麻克数来介导的。

结论

在出于医疗和非医疗原因使用大麻的人群中,大麻和酒精的日水平关联可能是互补的而不是替代的,而在医疗使用日减少大麻使用量(而不是增加)可能解释了使用大麻用于医疗目的与减少酒精使用之间的联系。尽管如此,当这些个体出于纯粹非医疗原因使用大麻时,他们可能会同时使用更多的大麻和酒精。

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