Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha 769008, India.
Cancer Drug Resistance Laboratory, Department of Life Science, National Institute of Technology Rourkela, Odisha 769008, India.
Arch Oral Biol. 2023 Jul;151:105697. doi: 10.1016/j.archoralbio.2023.105697. Epub 2023 Apr 13.
Oral cancer is the sixteenth most prevalent cancer in the world and the third-most in India. Despite of several treatment modalities, the cure rate of oral cancer is still low due to drug resistance mechanisms, which are caused by many reasons. It is necessary to improve the existing treatment strategies and discover neoteric therapy to kill cancer cells, which will give oral cancer's cure rate more success. So this review aims to delineate the molecular mechanisms behind cisplatin resistance, specifically the role of the tumor microenvironment, extracellular vesicles, and altered signaling pathways and its overcoming strategies in oral cancer.
This review was designed by searching words like cancer, oral cancer, cisplatin-resistance, tumor microenvironment, aberrant signalings, and extracellular vesicles, overcoming strategies for cisplatin resistance in databases like PubMed, Google Scholar, web science, and Scopus. Data available in this review is from 2017 to 2021.
After searching too much data, we found these 98 data appropriate for our review. From these data, we found that tumor microenvironment, extracellular vesicles, and altered signaling pathways like PI3K/AKT, EGFR, NOTCH, Ras, PTEN, Nf-κβ, and Wnt signaling have a crucial role in resistance development towards cisplatin in oral cancer.
Lastly, this review explores the alternative strategies to overcome cisplatin resistance likely, the combination therapy and targeted therapy by combining more than one chemotherapeutic drug or inhibitors of signaling pathways and also by using nanoparticle loaded drugs that will reduce the drug efflux, which gives new treatment strategies.
口腔癌是全球第 16 大常见癌症，也是印度第三大常见癌症。尽管有多种治疗方法，但由于耐药机制，口腔癌的治愈率仍然较低，这些耐药机制是由多种原因引起的。有必要改进现有的治疗策略并发现新的治疗方法来杀死癌细胞，这将使口腔癌的治愈率更有成效。因此，本综述旨在阐述顺铂耐药背后的分子机制，特别是肿瘤微环境、细胞外囊泡和改变的信号通路的作用及其在口腔癌中的克服策略。
本综述通过在 PubMed、Google Scholar、网络科学和 Scopus 等数据库中搜索“癌症、口腔癌、顺铂耐药、肿瘤微环境、异常信号和细胞外囊泡、克服顺铂耐药的策略”等词来设计。本综述中可用的数据来自 2017 年至 2021 年。
在搜索了大量数据后，我们发现这 98 项数据适合我们的综述。从这些数据中，我们发现肿瘤微环境、细胞外囊泡和改变的信号通路，如 PI3K/AKT、EGFR、NOTCH、Ras、PTEN、NF-κβ和 Wnt 信号通路，在口腔癌中对顺铂耐药的发展起着关键作用。
最后，本综述探讨了克服顺铂耐药的替代策略，可能是联合治疗和靶向治疗，通过联合使用一种以上的化疗药物或信号通路抑制剂，以及使用载药纳米颗粒来减少药物外排，从而提供新的治疗策略。
