Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan.
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Eur J Radiol. 2023 Jun;163:110808. doi: 10.1016/j.ejrad.2023.110808. Epub 2023 Apr 7.
Temporalis muscle thickness (TMT) is a surrogate marker for sarcopenia. This study investigated the association of TMT with clinical outcomes in patients receiving endovascular thrombectomy (EVT) for stroke involving acute large vessel occlusion (LVO).
We enrolled consecutive patients who had undergone EVT between September 2014 and December 2021 at three thrombectomy-capable institutes. TMT was measured through preprocedural computerized tomography angiography. The clinical variables affecting TMT were investigated. The associations between TMT and clinical functional outcomes, defined using the modified Rankin scale, were also studied.
A total of 657 patients were included (mean age: 72.0 ± 12.7 years; male: 52.1%). The mean TMT was 6.35 ± 1.84 mm. Younger age, male sex, higher body mass index, and premorbid functional independence were associated with larger TMT in both univariate and multivariate linear regression (P <.05). Ordinal logistic regression revealed that TMT was associated with better clinical outcomes at 90 days (P = 0.047); multivariate logistic regression indicated that larger TMT was an independent predictor (adjusted odds ratio: 1.14, 95% confidence interval: 1.03-1.27, P = 0.02) of favorable functional independence (modified Rankin scale score: 0-2). The effect was stronger in older patients (≥80 years) than younger patients, as revealed by interaction modeling analysis (P = 0.06).
TMT is associated with age, sex, body mass index, and premorbid functional status. Larger TMT is associated with better outcomes after EVT. The effects of TMT are more pronounced in older adults, indicating that sarcopenia may have influence on stroke outcomes.
颞肌厚度（TMT）是肌少症的替代标志物。本研究探讨了 TMT 与接受血管内血栓切除术（EVT）治疗伴有急性大血管闭塞（LVO）的卒中患者临床结局的相关性。
我们纳入了 2014 年 9 月至 2021 年 12 月在 3 个具备血栓切除术能力的机构接受 EVT 的连续患者。TMT 通过术前计算机断层血管造影术测量。研究了影响 TMT 的临床变量。还研究了 TMT 与使用改良 Rankin 量表定义的临床功能结局之间的相关性。
共纳入 657 例患者（平均年龄：72.0±12.7 岁；男性：52.1%）。平均 TMT 为 6.35±1.84mm。在单因素和多因素线性回归中，年龄较小、男性、较高的体重指数和术前功能独立性与 TMT 较大有关（P<.05）。有序逻辑回归显示，TMT 与 90 天的临床结局相关（P=0.047）；多因素逻辑回归表明，较大的 TMT 是良好功能独立性的独立预测因子（调整后的优势比：1.14，95%置信区间：1.03-1.27，P=0.02）。交互模型分析显示，在年龄较大（≥80 岁）的患者中，TMT 的影响更强（P=0.06）。
TMT 与年龄、性别、体重指数和术前功能状态有关。较大的 TMT 与 EVT 后更好的结局相关。TMT 的影响在老年人中更为明显，表明肌少症可能对卒中结局有影响。
