Hill M, Hillova J
Biomed Pharmacother. 1986;40(1):11-9.
When cells from a single culture are physically separated into cultures exposed and unexposed to the drug, respectively, the cells in the unexposed culture acquire drug resistance at a rate that is much higher than that predicted by Poisson's law. The results are in conflict with the spontaneous mutation hypothesis of Luria and Delbrück. Appendix: cells grown at 37 degrees C acquire temperature resistance when their close relatives are exposed to a high temperature in separate cultures.
当来自单一培养物的细胞被物理分离到分别暴露于和未暴露于该药物的培养物中时，未暴露培养物中的细胞获得耐药性的速率远高于泊松定律所预测的速率。这些结果与卢里亚和德尔布吕克的自发突变假说相矛盾。附录：当在37摄氏度下生长的细胞的近亲在单独培养物中暴露于高温时，这些细胞会获得耐热性。
