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Relationship between plasma propranolol concentration and dose in young, healthy volunteers.

作者信息

Dey M, Brisson J, Davis G, Enever R, Pray K, Zaim B, Dvornik D

出版信息

Biopharm Drug Dispos. 1986 Mar-Apr;7(2):103-11. doi: 10.1002/bdd.2510070202.

Abstract

The relationship between dose and bioavailability of propranolol was determined in 12 healthy male subjects. The doses employed were 10, 40, 80 or 160 mg of propranolol HCl given three times daily for 4 days. Daily minimum plasma levels showed that there was no accumulation of the drug. In all subjects, non-linear relationships were observed between peak plasma level, or area under the plasma concentration-time curve, and dose. The between subject variation of these parameters was not dose related.

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