Kopitar Z, Vrhova B, Lenardic A, Cvelbar P, Zorz M, Francetić I
Int J Clin Pharmacol Ther Toxicol. 1986 Jun;24(6):319-22.
The pharmacokinetics of orally administered propranolol in doses of 10, 40, 80 and 160 mg was studied in eight healthy volunteers in a cross-over trial. The analytical method applied made possible a parallel determination of propranolol and of 4-OH propranolol. The dose-dependent kinetics of orally administered propranolol was demonstrated. In our study linear dependence could be established only within a dosage range of 40 mg to 160 mg. Both substances determined in plasma, propranolol as well as 4-OH propranolol, show a tendency toward non-linearity, particularly at the lower dosage range between 10 and 40 mg.
在一项交叉试验中，对8名健康志愿者研究了口服剂量为10、40、80和160毫克普萘洛尔的药代动力学。所应用的分析方法能够同时测定普萘洛尔和4-羟基普萘洛尔。结果表明口服普萘洛尔具有剂量依赖性动力学。在我们的研究中，仅在40毫克至160毫克的剂量范围内可以建立线性关系。血浆中测定的两种物质，即普萘洛尔和4-羟基普萘洛尔，都显示出非线性趋势，特别是在10至40毫克的较低剂量范围内。
