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巨大左房黏液瘤:刚果民主共和国约 2 例切除。

Huge left atrial myxoma: about 2 cases resected in the Democratic Republic of Congo.

机构信息

Department of Thoracic and Cardiovascular Surgery, Kinshasa University Hospital, University of Kinshasa, BP 834, Kinshasa, Democratic Republic of the Congo.

Department of Cardiovascular Surgery, Ngaliema Clinic, Kinshasa, Democratic Republic of the Congo.

出版信息

J Cardiothorac Surg. 2023 Apr 20;18(1):156. doi: 10.1186/s13019-023-02286-2.

Abstract

BACKGROUND

Myxoma is the most common cardiac tumor, found in 75-80% of cases in the left atrium. It can grow quietly and therefore reach a large size before being symptomatic. Poor availability of echocardiography also contributes to delayed diagnosis. In Sub-Saharan African countries, myxoma diagnosis can be missed for many patients. Myxoma resection surgery, although technically simple, is not always possible, because of the lack of cardiac surgery development. The aim of this report is to describe the first two consecutive resection cases of huge left-atrial myxoma performed in Kinshasa, Democratic Republic of Congo (DRC) and to discuss the specificities of this surgery in this low-resource context.

CASE PRESENTATION

Two patients, 54 and 48 years old, were diagnosed with giant myxoma of the left atrium in the management of progressive dyspnea The first patient's transthoracic echocardiography revealed a pedunculated atrial mass (37 × 48 mm) on the interatrial septum, passing through the mitral valve. For the second patient, the mass (64 × 26 mm) was attached to the roof of the left atrium and protruded into the mitral valve, with significant mitro-tricuspid regurgitation The first patient underwent a simple resection of the myxoma. For the second patient, it was associated to a mitro-tricuspid annuloplasty. The postoperative course was simple for the first patient, but the second patient developed a biventricular failure requiring vasoactive drugs. Both patients were discharged alive from the hospital on postoperative days 10 and 12, respectively. They are regularly followed up and are doing well 2 years after surgery.

DISCUSSION AND CONCLUSION

Surgical resection is the only effective treatment of myxoma. Our first results are encouraging The poor availability of the echocardiography is a challenge in the diagnosis of myxoma. The development of cardiac surgery in DRC and ongoing country-level efforts to address diagnostic challenges for these often silent tumors will allow us to expect more resections to be performed locally and larger series published.

摘要

背景

黏液瘤是最常见的心脏肿瘤,在 75-80%的病例中发生于左心房。它可以安静地生长,因此在出现症状之前可以长到很大。超声心动图的可用性差也导致诊断延迟。在撒哈拉以南非洲国家,许多患者可能会错过黏液瘤的诊断。尽管黏液瘤切除术技术简单,但由于心脏外科学发展不足,并非总是可行。本报告的目的是描述在刚果民主共和国金沙萨连续完成的首例 2 例巨大左心房黏液瘤切除术,并讨论在这种资源匮乏的环境下进行这种手术的特殊性。

病例介绍

两名患者,年龄分别为 54 岁和 48 岁,在呼吸困难的治疗中被诊断为巨大左心房黏液瘤。第一例患者的经胸超声心动图显示房间隔上有一个带蒂的心房肿块(37×48mm),穿过二尖瓣。对于第二例患者,肿块(64×26mm)附着于左心房顶部并突入二尖瓣,伴有明显的二尖瓣三尖瓣反流。第一例患者接受了单纯的黏液瘤切除术。对于第二例患者,同时进行了二尖瓣三尖瓣环成形术。第一例患者术后恢复顺利,第二例患者则出现了双心室衰竭,需要使用血管活性药物。两名患者分别在术后第 10 天和第 12 天存活出院。他们在术后 2 年得到了定期随访,情况良好。

讨论和结论

手术切除是黏液瘤唯一有效的治疗方法。我们的初步结果令人鼓舞。超声心动图的可用性差是黏液瘤诊断的一个挑战。刚果民主共和国心脏外科学的发展以及为解决这些通常无症状肿瘤的诊断挑战而进行的国家一级的努力,将使我们能够期望更多的手术在当地进行,并发表更大规模的系列报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7697/10116768/3d77e0618101/13019_2023_2286_Fig1_HTML.jpg

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