Niiranen Toni J U, Chiollaz Anne-Cécile, Takala Riikka S K, Voutilainen Miko, Tenovuo Olli, Newcombe Virginia F J, Maanpää Henna-Riikka, Tallus Jussi, Mohammadian Mehrbod, Hossain Iftakher, van Gils Mark, Menon David K, Hutchinson Peter J, Sanchez Jean-Charles, Posti Jussi P
Department of Clinical Neurosciences, University of Turku, Turku, Finland.
Department of Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Front Neurol. 2023 Apr 4;14:1133764. doi: 10.3389/fneur.2023.1133764. eCollection 2023.
Interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) have gained interest as diagnostic biomarkers of traumatic brain injury (TBI), but factors affecting their blood levels in patients with moderate-to-severe TBI are largely unknown.
To investigate the trajectories of IL-10 and H-FABP between TBI patients with and without extracranial injuries (ECI); to investigate if there is a correlation between the levels of IL-10 and H-FABP with the levels of inflammation/infection markers C-reactive protein (CRP) and leukocytes; and to investigate if there is a correlation between the admission level of H-FABP with admission levels of cardiac injury markers, troponin (TnT), creatine kinase (CK), and creatine kinase MB isoenzyme mass (CK-MBm).
The admission levels of IL-10, H-FABP, CRP, and leukocytes were measured within 24 h post-TBI and on days 1, 2, 3, and 7 after TBI. The admission levels of TnT, CK, and CK-MBm were measured within 24 h post-TBI.
There was a significant difference in the concentration of H-FABP between TBI patients with and without ECI on day 0 (48.2 ± 20.5 and 12.4 ± 14.7 ng/ml, = 0.02, respectively). There was no significant difference in the levels of IL-10 between these groups at any timepoints. There was a statistically significant positive correlation between IL-10 and CRP on days 2 (R = 0.43, < 0.01) and 7 (R = 0.46, = 0.03) after injury, and a negative correlation between H-FABP and CRP on day 0 (R = -0.45, = 0.01). The levels of IL-10 or H-FABP did not correlate with leukocyte counts at any timepoint. The admission levels of H-FABP correlated with CK (R = 0.70, < 0.001) and CK-MBm (R = 0.61, < 0.001), but not with TnT.
Inflammatory reactions during the early days after a TBI do not significantly confound the use of IL-10 and H-FABP as TBI biomarkers. Extracranial injuries and cardiac sources may influence the levels of H-FABP in patients with moderate-to-severe TBI.
白细胞介素10（IL-10）和心脏脂肪酸结合蛋白（H-FABP）作为创伤性脑损伤（TBI）的诊断生物标志物受到关注，但影响中重度TBI患者血液中这些标志物水平的因素尚不清楚。
研究有无颅外损伤（ECI）的TBI患者中IL-10和H-FABP的变化轨迹；研究IL-10和H-FABP水平与炎症/感染标志物C反应蛋白（CRP）和白细胞水平之间是否存在相关性；研究H-FABP入院水平与心脏损伤标志物肌钙蛋白（TnT）、肌酸激酶（CK）和肌酸激酶MB同工酶质量（CK-MBm）入院水平之间是否存在相关性。
在TBI后24小时内以及TBI后第1、2、3和7天测量IL-10、H-FABP、CRP和白细胞的入院水平。在TBI后24小时内测量TnT、CK和CK-MBm的入院水平。
有ECI的TBI患者与无ECI的TBI患者在第0天的H-FABP浓度存在显著差异（分别为48.2±20.5和12.4±14.7 ng/ml，P = 0.02）。在任何时间点，两组间IL-10水平均无显著差异。损伤后第2天（R = 0.43，P < 0.01）和第7天（R = 0.46，P = 0.03），IL-10与CRP之间存在统计学显著正相关，第0天H-FABP与CRP之间存在负相关（R = -0.45，P = 0.01）。在任何时间点，IL-10或H-FABP水平与白细胞计数均无相关性。H-FABP入院水平与CK（R = 0.70，P < 0.001）和CK-MBm（R = 0.61，P < 0.001）相关，但与TnT无关。
TBI后早期的炎症反应不会显著干扰将IL-10和H-FABP用作TBI生物标志物。颅外损伤和心脏来源可能会影响中重度TBI患者的H-FABP水平。
Zotero 插件
