Reactions to radiographic contrast media: an attempt to detect specific anti-contrast medium antibodies in the sera of reactor patients.

A radioimmunoassay was used in an attempt to detect specific anti-contrast medium antibodies in the sera of a group of 68 patients who reacted to radiographic contrast media and a group of 30 age-, sex- and disease-matched control patients who did not react. No evidence of specific antibodies of the IgG or IgE classes was demonstrated in these two groups. The results suggest the lack of an antibody-mediated aetiology for reactions to radiographic contrast media.