Shenzhen Key Laboratory of Interfacial Science and Engineering of Materials, Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, P. R. China.
Key University Laboratory of Highly Efficient Utilization of Solar Energy and Sustainable Development of Guangdong, Southern University of Science and Technology, Shenzhen 518055, P. R. China.
J Mater Chem B. 2023 May 10;11(18):4065-4075. doi: 10.1039/d2tb02399g.
Photothermal nanomaterials have shown great potential for photothermal therapy. In this study, we developed a simple green method of magnesiothermic co-reduction for the synthesis of mesoporous, magnetic and biodegradable iron silicide nanoparticles (FeSi NPs) as applied to photothermal therapy (PTT). Starting from biogenic tabasheer extracted from bamboo and FeO, the resultant FeSi NPs with a much lower band gap exhibited excellent optical absorption with a photothermal conversion efficiency of 76.2%, indicating a good photothermal performance. The weight extinction coefficient was measured to be 13.3 L g cm at 1064 nm (second near-infrared window, NIR-II), which surpassed the performance of other competitive Si-based and Fe-based photothermal agents. Results of the cell viability assay showed that cells could be killed by NIR-II laser irradiation with the synthesized FeSi NPs. results on mice showed clearly an efficient suppression of tumour growth by photothermal treatment with FeSi NPs. FeSi NPs were found to be biodegradable in simulated body fluids. The results from our work indicate that FeSi NPs are a new class of promising photothermal agents (PTAs) for application in cancer therapy.
光热纳米材料在光热治疗中显示出巨大的潜力。在这项研究中，我们开发了一种简单的绿色镁热共还原方法，用于合成介孔、磁性和可生物降解的铁硅化物纳米粒子（FeSi NPs），用于光热治疗（PTT）。从竹中提取的生物法塔什和 FeO 开始，所得的 FeSi NPs 具有更低的带隙，表现出优异的光吸收性能，光热转换效率为 76.2%，表明具有良好的光热性能。在 1064nm 处（近红外二区，NIR-II）测量的重量消光系数为 13.3Lgcm，超过了其他竞争的 Si 基和 Fe 基光热剂的性能。细胞活力测定结果表明，用合成的 FeSi NPs 可以通过近红外二区激光照射杀死细胞。在小鼠身上的研究结果清楚地表明，用 FeSi NPs 进行光热治疗可以有效地抑制肿瘤生长。FeSi NPs 在模拟体液中被发现是可生物降解的。我们的工作结果表明，FeSi NPs 是一类有前途的用于癌症治疗的新型光热剂（PTAs）。
