Division of Microbiology, Department of Biochemistry, Genetics, and Microbiology, University of Pretoria, Hatfield, Pretoria, South Africa.
Department of Plant and Soil Sciences, University of Pretoria, Hatfield, Pretoria, South Africa.
Microbiology (Reading). 2023 Apr;169(4). doi: 10.1099/mic.0.001326.
Unprecedented insights into the biology and functions of bacteria have been and continue to be gained through studying bacterial secretion systems in isolation. This method, however, results in our understanding of the systems being primarily based on the idea that they operate independently, ignoring the subtleties of downstream interconnections. Gram-negative bacteria are naturally able to adapt to and navigate their frequently varied and dynamic surroundings, mostly because of the covert connections between secretion systems. Therefore, to comprehend some of the linked downstream repercussions for organisms that follow this discourse, it is vital to have mechanistic insights into how the intersecretion system functions in bacterial rivalry, virulence, and survival, among other things. To that purpose, this paper discusses a few key instances of molecular antagonistic and interdependent relationships between bacterial secretion systems and their produced functional products.
通过研究独立的细菌分泌系统，人们对细菌的生物学和功能有了前所未有的深入了解。然而，这种方法导致我们对这些系统的理解主要基于它们独立运作的观点，忽略了下游相互连接的细微差别。革兰氏阴性菌能够自然地适应和探索其经常变化和动态的环境，这主要是因为分泌系统之间存在隐蔽的联系。因此，为了理解遵循这一论述的生物体的一些相关的下游影响，深入了解分泌系统在细菌竞争、毒力和生存等方面的相互作用机制至关重要。为此，本文讨论了细菌分泌系统及其产生的功能产物之间的一些关键分子拮抗和相互依存关系实例。
