G5 Biologie structurale de la sécrétion bactérienne, CNRS UMR 3528, Paris, France, and Institut Pasteur, Institut Pasteur, Paris, France, and Laboratoire de Microbiologie Fondamentale et Pathogénicité, CNRS UMR 5234, Institut Européen de Chimie et Biologie, Pessac, France, and Université de Bordeaux, Pessac, France.
Curr Issues Mol Biol. 2018;25:1-42. doi: 10.21775/cimb.025.001. Epub 2017 Sep 6.
In this review we examine the use of secretion systems by bacteria to subvert host functions. Bacteria have evolved multiple systems to interact with and overcome their eukaryotic host and other prokaryotes. Secretion systems are required for the release of several effectors through the bacterial membrane(s) into the extracellular space or directly into the cytoplasm of the host. We review the secretion systems of Gram-positive and Gram-negative bacteria and describe briefly the structural composition of the seven secretion systems that have been associated with increased virulence through subversion of host functions. Some of the effects of such systems on eukaryotic host processes have been studied extensively. We also describe the best-characterized effectors of each secretion system to give an overview of the molecular mechanisms employed by bacteria to hide from the immune system and convert eukaryotic cells into optimal ecological niches for their replication.
在这篇综述中，我们研究了细菌利用分泌系统来颠覆宿主功能。细菌已经进化出多种系统来与真核宿主和其他原核生物相互作用并克服它们。分泌系统是将几种效应物通过细菌膜释放到细胞外空间或直接进入宿主细胞质所必需的。我们综述了革兰氏阳性菌和革兰氏阴性菌的分泌系统，并简要描述了与通过颠覆宿主功能而增加毒力相关的七种分泌系统的结构组成。已经广泛研究了这些系统对真核宿主过程的一些影响。我们还描述了每个分泌系统的特征最明显的效应物，以概述细菌用来躲避免疫系统并将真核细胞转化为其复制的最佳生态位的分子机制。
