1Department of Veterinary Surgery and Anestesiology, Faculty of Veterinary Medicine, Universidade do Oeste Paulista, Presidente Prudente, Brazil.
2Neuropet, Veterinary Clinic, Belém, Brazil.
J Am Vet Med Assoc. 2023 Apr 21;261(9):1297-1304. doi: 10.2460/javma.23.02.0117. Print 2023 Sep 1.
To evaluate the efficacy and safety of bromelain to control pain and inflammation in cats undergoing ovariohysterectomy.
30 client-owned cats undergoing ovariohysterectomy.
In a randomized, blinded clinical study, cats were assigned to receive either oral bromelain suspension (40 mg/kg [18 mg/lb]; BG, n = 15) or placebo solution (0.1 mL/kg [0.045 mL/lb]; PG, 15), which were administered 90 minutes before and 12 hours after surgery. The anesthetic protocol included acepromazine, meperidine, propofol, and isoflurane. Pain and sedation were assessed at various time points up to 24 hours post-extubation using the UNESP-Botucatu multidimensional composite pain scale, the Glasgow feline composite measure pain scale, and a descriptive numerical scale. Surgical wound inflammation was measured at the same time points, using a numeric rating scale. Morphine was administered as rescue analgesia. Laboratory data (urea, creatinine, gamma-glutamyl transferase, alkaline phosphatase, the prothrombin time, and the fecal occult blood) were analyzed preoperatively and 24 hours after surgery.
Pain/inflammation scores, and analgesic requirements did not differ between groups. Shorter recovery time and lower sedation scores were recorded during the first hour post-extubation in the BG than the PG. Postoperatively, serum creatinine and gamma-glutamyl transferase were lower in the BG compared to PG. Compared to baseline values, all biochemistry variables decreased at 24 hours in the BG. The prothrombin time and fecal occult blood did not differ between groups or over time.
Bromelain did not provide significant analgesic and anti-inflammatory benefits over placebo in cats undergoing ovariohysterectomy.
评估菠萝蛋白酶控制行卵巢子宫切除术的猫疼痛和炎症的疗效和安全性。
30 只接受卵巢子宫切除术的患宠猫。
在一项随机、双盲临床研究中，将猫分为口服菠萝蛋白酶混悬液（40mg/kg[18mg/lb]；BG 组，n=15）或安慰剂溶液（0.1ml/kg[0.045ml/lb]；PG 组，15）组，分别在手术前 90 分钟和手术后 12 小时给予。麻醉方案包括乙酰丙嗪、哌替啶、异丙酚和异氟烷。使用 UNESP-Botucatu 多维综合疼痛量表、格拉斯哥猫综合疼痛量表和描述性数字量表，在拔管后 24 小时内的不同时间点评估疼痛和镇静程度。使用数字评分量表，在相同时间点测量手术伤口炎症。给予吗啡作为解救镇痛。分析术前和术后 24 小时的实验室数据（尿素、肌酐、γ-谷氨酰转移酶、碱性磷酸酶、凝血酶原时间和粪便潜血）。
两组的疼痛/炎症评分和镇痛需求无差异。BG 组在拔管后 1 小时内的恢复时间更短，镇静评分更低。与 PG 组相比，BG 组术后血清肌酐和γ-谷氨酰转移酶较低。与基线值相比，BG 组在 24 小时时所有生化变量均降低。凝血酶原时间和粪便潜血在组间或随时间无差异。
与安慰剂相比，菠萝蛋白酶在接受卵巢子宫切除术的猫中没有提供显著的镇痛和抗炎益处。
