Department of Nephrology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Department of Nephrology, The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China; Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia, USA.
Kidney Int. 2023 May;103(5):833-835. doi: 10.1016/j.kint.2023.02.009.
Micropeptides are small proteins encoded by short open reading frames mostly located in long noncoding RNAs. Mitoregulin (MOXI) is a nuclear encoded micropeptide initially identified in the inner mitochondrial membrane to regulate fatty acid β-oxidation. In this issue of Kidney International, Li et al. report that MOXI is upregulated in both human fibrotic kidneys and murine models of renal fibrosis. Remarkably, MOXI functions in the nucleus, where it forms a transcriptional complex with N-acetyltransferase 14 and c-Jun to facilitate the expression of fibrotic genes. By working in the nucleus and mitochondria, MOXI may channel the 2-way communication between these organelles, adding a new layer of complexity in the cell biology of renal fibrogenesis.
微肽是由短开放阅读框编码的小蛋白，主要位于长非编码 RNA 中。Mitoregulin (MOXI) 是一种核编码的微肽，最初在 线粒体 内膜中被鉴定出来，以调节脂肪酸β-氧化。在本期《国际肾脏杂志》中，Li 等人报道 MOXI 在人类纤维化肾脏和 肾纤维化 小鼠模型中均上调。值得注意的是，MOXI 在 核 中发挥作用，在那里它与 N-乙酰转移酶 14 和 c-Jun 形成转录复合物，促进纤维化基因的表达。MOXI 通过在 核 和 线粒体 中发挥作用，可能为这两个细胞器之间的双向通信提供渠道，为 肾纤维化 的细胞生物学增加了一个新的复杂性层次。
