维生素 D 缺乏与糖尿病视网膜病变风险。

Vitamin D deficiency and diabetic retinopathy risk.

机构信息

Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran.

出版信息

J Fr Ophtalmol. 2023 Sep;46(7):737-741. doi: 10.1016/j.jfo.2023.01.024. Epub 2023 Apr 19.

DOI:10.1016/j.jfo.2023.01.024

PMID:37085359

Abstract

PURPOSE

Vitamin D deficiency may play an important role in the development and progression of diabetic retinopathy. The present study aimed to assess the relationship between vitamin D deficiency and the likelihood of diabetic retinopathy.

METHODS

This nested case-control study was conducted on all type II diabetic patients among the participants of the third phase of the Shahroud eye cohort study. Overall, 278 patients aged 50 to 74 years, 101 in the case group (diabetic retinopathy) and 178 in the control group (diabetic without retinopathy), were assessed. Serum levels of vitamin D on admission were measured for all participants by a radio immunoassay (RIA) technique.

RESULTS

The overall prevalence of vitamin D deficiency (defined as a vitamin D level of less than or equal to 20mg/dL) was 30.7%. Comparison of the serum level of vitamin D across the three groups - without retinopathy, with non-proliferative retinopathy, and with proliferative retinopathy - showed a significantly lower level of this marker in the latter group (P=0.036). Reducing vitamin D to less than or equal to 20ng/mL increased the odds of proliferative retinopathy by 6.25 times (P value: 0.027).

CONCLUSION

Vitamin D deficiency is a potential risk factor for diabetes-related proliferative retinopathy.

摘要

目的

维生素 D 缺乏可能在糖尿病性视网膜病变的发生和发展中起重要作用。本研究旨在评估维生素 D 缺乏与糖尿病性视网膜病变发生的相关性。

方法

本巢式病例对照研究纳入 Shahroud 眼队列研究第三阶段的所有 2 型糖尿病患者。共有 278 名年龄在 50 至 74 岁的患者参与，其中 101 例为病例组（糖尿病性视网膜病变），178 例为对照组（无糖尿病性视网膜病变）。所有参与者入院时均采用放射免疫分析法（RIA）检测血清维生素 D 水平。

结果

维生素 D 缺乏（定义为血清维生素 D 水平≤20mg/dL）的总患病率为 30.7%。比较无视网膜病变、非增殖性视网膜病变和增殖性视网膜病变三组的血清维生素 D 水平，发现后者的该标志物水平显著较低（P=0.036）。将维生素 D 降低至≤20ng/mL 会使增殖性视网膜病变的发生风险增加 6.25 倍（P 值：0.027）。