Aozasa K, Inoue A, Tajima K, Miyauchi A, Matsuzuka F, Kuma K
Cancer. 1986 Jul 1;58(1):100-4. doi: 10.1002/1097-0142(19860701)58:1<100::aid-cncr2820580118>3.0.co;2-1.
Prognostic factors in 79 patients with malignant lymphomas involving the thyroid gland were analyzed. These patients suffered from progressively enlarging goiter with over 6 months duration in 60% of patients. The age at operation ranged from 16 to 80 years (median, 58 years). Male to female ratio was 1:1.8. Serum tests for antithyroid antibodies were positive in 83% of the patients, who also showed histologic evidence of chronic lymphocytic thyroiditis. Histologically, 52 cases (66%) were germinal center cell tumors with follicular or follicular and diffuse pattern in 9 cases. By the Working Formulation, 5-year survival rate of immunoblastic type (IBL) (13%) was much poorer than those of intermediate (79%) and low grade cases (92%) (P less than 0.001). The cases of IBL usually had a goiter of short duration, and frequently presented as advanced disease.
对79例累及甲状腺的恶性淋巴瘤患者的预后因素进行了分析。这些患者患有进行性肿大的甲状腺肿，60%的患者病程超过6个月。手术年龄范围为16至80岁（中位数为58岁）。男女比例为1:1.8。83%的患者抗甲状腺抗体血清检测呈阳性，这些患者还显示出慢性淋巴细胞性甲状腺炎的组织学证据。组织学上，52例（66%）为生发中心细胞肿瘤，9例为滤泡型或滤泡和弥漫型。根据工作分类法，免疫母细胞型（IBL）的5年生存率（13%）远低于中度（79%）和低度病例（92%）（P<0.001）。IBL病例通常甲状腺肿病程短，且常表现为晚期疾病。
