Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Sci Rep. 2023 Apr 21;13(1):6589. doi: 10.1038/s41598-023-33672-4.
We evaluated the impact of the influenza season on outcome of new lung nodules in a LDCT lung cancer screening trial population. NELSON-trial participants with ≥ 1 new nodule detected in screening rounds two and three were included. Outcome (resolution or persistence) of new nodules detected per season was calculated and compared. Winter (influenza season) was defined as 1st October to 31st March, and compared to the summer (hay-fever season), 1st April to 30th September. Overall, 820 new nodules were reported in 529 participants. Of the total new nodules, 482 (59%) were reported during winter. When considering the outcome of all new nodules, there was no statistically significant association between summer and resolving nodules (OR 1.07 [CI 1.00-1.15], p = 0.066), also when looking at the largest nodule per participant (OR 1.37 [CI 0.95-1.98], p = 0.094). Similarly, there was no statistically significant association between season and screen detected cancers (OR 0.47 [CI 0.18-1.23], p = 0.123). To conclude, in this lung cancer screening population, there was no statistically significant association between influenza season and outcome of new lung nodules. Hence, we recommend new nodule management strategy is not influenced by the season in which the nodule is detected.
我们评估了流感季节对 LDCT 肺癌筛查试验人群中新结节结局的影响。纳入了在筛查轮次 2 和 3 中检测到≥1 个新结节的 NELSON 试验参与者。按季节计算和比较每个季节新结节的结局（消退或持续存在）。冬季（流感季节）定义为 10 月 1 日至 3 月 31 日，与夏季（花粉热季节）4 月 1 日至 9 月 30 日进行比较。总体而言，529 名参与者中报告了 820 个新结节。在所有新结节中，482 个（59%）发生在冬季。考虑所有新结节的结局时，夏季与结节消退之间无统计学显著关联（OR 1.07 [CI 1.00-1.15]，p=0.066），当观察每位参与者最大的结节时也是如此（OR 1.37 [CI 0.95-1.98]，p=0.094）。同样，季节与筛查发现的癌症之间也无统计学显著关联（OR 0.47 [CI 0.18-1.23]，p=0.123）。总之，在该肺癌筛查人群中，流感季节与新发肺结节的结局之间无统计学显著关联。因此，我们建议新结节管理策略不受结节检出季节的影响。
