Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
Aging (Albany NY). 2023 Apr 21;15(8):2852-2862. doi: 10.18632/aging.204667.
Wound healing is an essential physiological process for restoring normal skin structure and function post-injury. The role of cellular senescence, an essentially irreversible cell cycle state in response to damaging stimuli, has emerged as a critical mechanism in wound remodeling. Transiently-induced senescence during tissue remodeling has been shown to be beneficial in the acute wound healing phase. In contrast, persistent senescence, as observed in chronic wounds, contributes to delayed closure. Herein we describe a chronic wound murine model and its cellular senescence profile, including the senescence-associated secretory phenotype.
伤口愈合是一种重要的生理过程，可在受伤后恢复正常的皮肤结构和功能。细胞衰老作为一种应对损伤刺激的不可逆细胞周期状态，在伤口重塑中起着关键作用。在组织重塑过程中诱导的短暂衰老已被证明在急性伤口愈合阶段是有益的。相反，在慢性伤口中观察到的持续衰老会导致愈合延迟。本文描述了一种慢性伤口小鼠模型及其细胞衰老特征，包括衰老相关分泌表型。
