Pajic-Lijakovic Ivana, Eftimie Raluca, Milivojevic Milan, Bordas Stéphane P A
University of Belgrade, Faculty of Technology and Metallurgy, Department of Chemical Engineering, Serbia.
Laboratoire Mathematiques de Besançon, UMR-CNRS 6623, Université de Bourgogne Franche-Comte, 16 Route de Gray, Besançon 25000, France.
Adv Colloid Interface Sci. 2023 May;315:102902. doi: 10.1016/j.cis.2023.102902. Epub 2023 Apr 7.
Tissue surface tension is one of the key parameters that govern tissue rearrangement, shaping, and segregation within various compartments during organogenesis, wound healing, and cancer diseases. Deeper insight into the relationship between tissue surface tension and cell residual stress accumulation caused by collective cell migration can help us to understand the multi-scale nature of cell rearrangement with pronounced oscillatory trend. Oscillatory change of cell velocity that caused strain and generated cell residual stress were discussed in the context of mechanical waves. The tissue surface tension also showed oscillatory behaviour. The main goal of this theoretical consideration is to emphasize an inter-relation between various scenarios of cell rearrangement and tissue surface tension by distinguishing liquid-like and solid-like surfaces. This complex phenomenon is discussed in the context of an artificial tissue model system, namely cell aggregate rounding after uni-axial compression between parallel plates. Experimentally obtained oscillatory changes in the cell aggregate shape during the aggregate rounding, which is accompanied by oscillatory decrease in the aggregate surface area, points to oscillatory changes in the tissue surface tension. Besides long-time oscillations, cell surface tension can perform short time relaxation cycles. This behaviour of the tissue surface tension distinguishes living matter from other soft matter systems. This complex phenomenon is discussed based on dilatational viscoelasticity and thermodynamic approach.
组织表面张力是在器官发生、伤口愈合和癌症疾病过程中，控制组织在各个腔室内重新排列、塑形和分离的关键参数之一。更深入地了解组织表面张力与集体细胞迁移引起的细胞残余应力积累之间的关系，有助于我们理解具有明显振荡趋势的细胞重排的多尺度性质。在机械波的背景下，讨论了由应变引起的细胞速度振荡变化以及产生的细胞残余应力。组织表面张力也表现出振荡行为。这一理论思考的主要目标是通过区分类液体表面和类固体表面，强调细胞重排的各种情况与组织表面张力之间的相互关系。在一个人工组织模型系统的背景下讨论了这种复杂现象，即平行板之间单轴压缩后细胞聚集体的圆形化。实验获得的细胞聚集体圆形化过程中聚集体形状的振荡变化，伴随着聚集体表面积的振荡减小，表明组织表面张力存在振荡变化。除了长时间振荡外，细胞表面张力还可以进行短时间的松弛循环。组织表面张力的这种行为将生命物质与其他软物质系统区分开来。基于膨胀粘弹性和热力学方法讨论了这种复杂现象。
