Karadjov J S, Zinchenko V P
Cell Calcium. 1986 Apr;7(2):115-9. doi: 10.1016/0143-4160(86)90014-x.
Tetraphenylphosphonium (TPP+) inhibits Na+-stimulated Ca2+ efflux from brain mitochondria. Half inhibition is observed when 1.10(-8)M TPP+ is present in the medium. Some other lipophylic cations show similar effect. TPP+ must be used carefully for measuring transmembrane potential because of its effects on the system studied. TPP+ will be a useful tool to study Ca-transport system in mitochondria.
四苯基鏻离子（TPP+）可抑制脑线粒体中由钠离子刺激引起的钙离子外流。当培养基中存在1.10(-8)M的TPP+时，可观察到半数抑制作用。其他一些亲脂性阳离子也表现出类似的作用。由于TPP+对所研究系统有影响，因此在测量跨膜电位时必须谨慎使用。TPP+将成为研究线粒体中钙转运系统的有用工具。
