探究白屈菜红碱在乳腺癌治疗中的应用潜力。

Insights into the potential of Sanguinarine as a promising therapeutic option for breast cancer.

机构信息

Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics, School of Science, GITAM (Deemed to be University), Visakhapatnam 530045, Andhra Pradesh, India.

出版信息

Biochem Pharmacol. 2023 Jun;212:115565. doi: 10.1016/j.bcp.2023.115565. Epub 2023 Apr 20.

DOI:10.1016/j.bcp.2023.115565

PMID:37086811

Abstract

Breast cancer (BC) is one of the leading causes of cancer-related deaths in women worldwide. The tumor microenvironment (TME) plays a crucial role in the progression and metastasis of BC. A significant proportion of BC is characterized by a hypoxic TME, which contributes to the development of drug resistance and cancer recurrence. Sanguinarine (SAN), an isoquinoline alkaloid found in Papaver plants, has shown promise as an anticancer agent. The present review focuses on exploring the molecular mechanisms of hypoxic TME in BC and the potential of SAN as a therapeutic option. The review presents the current understanding of the hypoxic TME, its signaling pathways, and its impact on the progression of BC. Additionally, the review elaborates on the mechanisms of action of SAN in BC, including its effects on vital cellular processes such as proliferation, migration, drug resistance, and tumor-induced immune suppression. The review highlights the importance of addressing hypoxic TME in treating BC and the potential of SAN as a promising therapeutic option.

摘要

乳腺癌（BC）是全球女性癌症相关死亡的主要原因之一。肿瘤微环境（TME）在 BC 的进展和转移中起着关键作用。相当一部分 BC 的特点是缺氧 TME，这导致了耐药性和癌症复发的发展。血根碱（SAN）是罂粟属植物中发现的一种异喹啉生物碱，已被证明是一种有前途的抗癌药物。本综述重点探讨了 BC 缺氧 TME 的分子机制以及 SAN 作为治疗选择的潜力。该综述介绍了对缺氧 TME 的当前理解，包括其信号通路及其对 BC 进展的影响。此外，该综述详细阐述了 SAN 在 BC 中的作用机制，包括其对增殖、迁移、耐药性和肿瘤诱导免疫抑制等重要细胞过程的影响。该综述强调了在治疗 BC 中解决缺氧 TME 的重要性以及 SAN 作为一种有前途的治疗选择的潜力。