Malla RamaRao, Surepalli Nagalakshmi, Farran Batoul, Malhotra Sanjay V, Nagaraju Ganji Purnachandra
Cancer Biology Lab, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM (Deemed to be University), Visakhapatnam, 530045, India.
Dr. B.R. Ambedkar Open University, Hyderabad, Telangana, 500033, India.
Crit Rev Oncol Hematol. 2021 Apr;160:103285. doi: 10.1016/j.critrevonc.2021.103285. Epub 2021 Mar 11.
Increases in Reactive oxygen species (ROS) have been reported in breast tumors and their surrounding tumor microenvironment (TME) cells. ROS are critical factors in breast TME as they ensure bidirectional communication among various components and mediate multi-faceted roles in tumor progression and metastasis. This paper presents a detailed and comprehensive review of the studies exploring ROS and various forms of oxidative stress in cancer progression, specifically breast cancer (BC), its microenvironment and associated cell types. The paper focuses on several diverse aspects of cellular and molecular biology of cancer, with pharmacological implications of phytochemicals in BC. We also describe the role of ROS in the genetic and epigenetic reprogramming of the TME, metastasis, and drug resistance as well as regulators of BC TME. Additionally, we discuss ROS-mediated TME therapy and the therapeutic conundrum of breast TME. These contributions could prompt the development of personalized anti-cancer drugs for the treatment of highly complex and aggressive BCs.
据报道，乳腺肿瘤及其周围肿瘤微环境（TME）细胞中的活性氧（ROS）水平会升高。ROS是乳腺TME中的关键因素，因为它们确保了各种成分之间的双向通信，并在肿瘤进展和转移中发挥多方面作用。本文对探索ROS以及癌症进展（特别是乳腺癌（BC））、其微环境和相关细胞类型中各种形式氧化应激的研究进行了详细而全面的综述。本文重点关注癌症细胞和分子生物学的几个不同方面，以及植物化学物质在BC中的药理学意义。我们还描述了ROS在TME的遗传和表观遗传重编程、转移和耐药性以及BC TME调节因子中的作用。此外，我们讨论了ROS介导的TME治疗以及乳腺TME的治疗难题。这些研究成果可能会推动开发用于治疗高度复杂和侵袭性BC的个性化抗癌药物。
