Patel Ranish K, Parappilly Michael, Sutton Thomas L, Behrens Shay, Schwantes Issac R, Johnson Alicia J, Pommier Rodney F, Sheppard Brett C
Oregon Heath & Science University (OHSU), Department of Surgery, Division of General Surgery, Portland, OR, 97239, USA.
Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, 2720 S. Moody Ave., Mailcode KC-CDCB, Portland, OR, 97201, USA.
Am J Surg. 2024 May;231:55-59. doi: 10.1016/j.amjsurg.2023.04.010. Epub 2023 Apr 18.
Pancreatic acinar cell carcinoma (PACC) is a rare exocrine tumor of the pancreas. We evaluated the effect disease stage, surgical intervention, and institutional volume status plays in survival.
We queried the Oregon State Cancer Registry for patients with PACC from 1997 to 2018. Treatment and referral patterns were analyzed, and overall survival (OS) was evaluated with Kaplan-Meier and Cox-proportional hazard analysis.
43 patients were identified. Median OS was 33.1 and 7.1 months in those with locoregional and metastatic disease respectively (p = 0.008). Surgical intervention was associated with improved OS (hazard ratio 0.28, p < 0.0001). High volume center (HVC) care trended towards improving OS. While the majority of cases were diagnosed at low volume centers (74%), referral to HVCs was rare (n = 4) and limited to advanced (stage III/IV) disease.
Stage and surgical resection influence survival outcomes in PACC, more data is needed to delineate the impact of institutional volume status.
胰腺腺泡细胞癌（PACC）是一种罕见的胰腺外分泌肿瘤。我们评估了疾病分期、手术干预和机构容量状态对生存的影响。
我们查询了俄勒冈州癌症登记处1997年至2018年期间患有PACC的患者。分析了治疗和转诊模式，并采用Kaplan-Meier法和Cox比例风险分析法评估总生存期（OS）。
共识别出43例患者。局部区域疾病和转移性疾病患者的中位OS分别为33.1个月和7.1个月（p = 0.008）。手术干预与OS改善相关（风险比0.28，p < 0.0001）。高容量中心（HVC）治疗有改善OS的趋势。虽然大多数病例在低容量中心确诊（74%），但转诊至HVC的情况很少见（n = 4），且仅限于晚期（III/IV期）疾病。
分期和手术切除影响PACC的生存结果，需要更多数据来阐明机构容量状态的影响。
