Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450052, P. R. China.
Org Lett. 2023 May 5;25(17):2953-2957. doi: 10.1021/acs.orglett.3c00531. Epub 2023 Apr 23.
Described herein is the development of an unprecedented approach to construct multiple heterocycles with high selectivity through Rh(III)-catalyzed two- or three-component cyclization reaction from simple and readily available starting materials: -methoxybenzamides, 2-butyne biscarbonate, and maleimides. This methodology provides an efficient strategy for the synthesis of diverse and complicated heterocycles in a one-pot manner and displays excellent features of extremely mild reaction conditions, easy operation, excellent regioselectivity, and good functional group compatibility.
本文描述了一种前所未有的方法的发展，通过 Rh(III)-催化的二或三组分环化反应，从简单易得的起始原料 - 甲氧基苯甲酰胺、2-丁炔二羧酸酯和马来酰亚胺中，高选择性地构建多种杂环。这种方法为一锅法合成各种复杂的杂环提供了一种有效的策略，具有反应条件非常温和、操作简单、区域选择性好、官能团兼容性好等特点。
