Chen Lei, Liu Cui, Xue Yan, Chen Xin-Yi
Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China.
Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China.
Neuropeptides. 2023 Jun;99:102337. doi: 10.1016/j.npep.2023.102337. Epub 2023 Apr 15.
Parkinson's disease is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. The surviving nigral dopaminergic neurons display altered spontaneous firing activity in Parkinson's disease. The firing rate of nigral dopaminergic neurons decreases long before complete neuronal death and the appearance of parkinsonian symptoms. A mild stimulation could rescue dopaminergic neurons from death and in turn play neuroprotective effects. Several neuropeptides, including cholecystokinin (CCK), ghrelin, neurotensin, orexin, tachykinins and apelin, within the substantia nigra pars compacta play important roles in the modulation of spontaneous firing activity of dopaminergic neurons and therefore involve motor control and motor disorders. Here, we review neuropeptide-induced modulation of the firing properties of nigral dopaminergic neurons. This review may provide a background to guide further investigations into the involvement of neuropeptides in movement control by modulating firing activity of nigral dopaminergic neurons in Parkinson's disease.
帕金森病的特征是黑质致密部多巴胺能神经元进行性退化。在帕金森病中，存活的黑质多巴胺能神经元表现出自发放电活动改变。在神经元完全死亡和帕金森症状出现之前很久，黑质多巴胺能神经元的放电频率就会降低。轻度刺激可以挽救多巴胺能神经元免于死亡，进而发挥神经保护作用。黑质致密部的几种神经肽，包括胆囊收缩素（CCK）、胃饥饿素、神经降压素、食欲素、速激肽和阿片肽，在调节多巴胺能神经元的自发放电活动中起重要作用，因此涉及运动控制和运动障碍。在此，我们综述神经肽对黑质多巴胺能神经元放电特性的调节作用。本综述可为进一步研究神经肽通过调节帕金森病中黑质多巴胺能神经元的放电活动参与运动控制提供背景资料。
