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啮齿动物挫伤性脊髓损伤的有限元模型。

A finite element model of contusion spinal cord injury in rodents.

机构信息

School of Mechanical & Manufacturing Engineering, Dublin City University, Dublin, Ireland.

School of Medicine, University College Dublin, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland.

出版信息

J Mech Behav Biomed Mater. 2023 Jun;142:105856. doi: 10.1016/j.jmbbm.2023.105856. Epub 2023 Apr 17.


DOI:10.1016/j.jmbbm.2023.105856
PMID:37087955
Abstract

Traumatic spinal cord injuries result from high impact forces acting on the spine and are proceeded by an extensive secondary inflammatory response resulting in motor, sensory, and autonomic dysfunction. Experimental in vivo traumatic spinal cord injuries in rodents using a contusion model have been extremely useful in elucidating the underlying pathophysiology of these injuries. However, the relationship between the pathophysiology and the biomechanical factors is still not well understood. Therefore, the aim of this research is to provide a comprehensive analysis of the biomechanics of traumatic spinal cord injury in a rat contusion model. This is achieved through the development and validation of a finite element model of the thoracic rat spinal cord and subsequently simulating controlled cortical impact-induced traumatic spinal cord injury. The effects of impactor velocity, depth, and geometry on the resulting stresses and strains within the spinal cord are investigated. Our results show that increasing impactor depth results in larger stresses and strains within the spinal cord tissue as expected. Further, for the first time ever our results show that impactor geometry (spherical versus cylindrical) plays an important role in the distribution and magnitude of stresses and strains within the cord. Therefore, finite element modelling can be a powerful tool used to predict stresses and strains that occur in spinal cord tissue during trauma.

摘要

外伤性脊髓损伤是由于脊柱受到高冲击力作用引起的,随后会发生广泛的继发性炎症反应,导致运动、感觉和自主功能障碍。在啮齿动物中使用挫伤模型进行的实验性外伤性脊髓损伤,对于阐明这些损伤的潜在病理生理学非常有用。然而,病理生理学和生物力学因素之间的关系仍未得到很好的理解。因此,本研究的目的是提供对大鼠挫伤模型外伤性脊髓损伤的生物力学的全面分析。这是通过开发和验证胸段大鼠脊髓的有限元模型,并随后模拟皮质控制冲击诱导的外伤性脊髓损伤来实现的。研究了冲击器速度、深度和几何形状对脊髓内产生的应力和应变的影响。我们的结果表明,冲击器深度的增加会导致脊髓组织内的应力和应变增大,这是预期的结果。此外,我们的结果首次表明,冲击器几何形状(球形与圆柱形)在脊髓内的应力和应变分布和大小中起着重要作用。因此,有限元建模可以成为一种强大的工具,用于预测在创伤过程中脊髓组织中发生的应力和应变。

相似文献

[1]
A finite element model of contusion spinal cord injury in rodents.

J Mech Behav Biomed Mater. 2023-6

[2]
Impact depth and the interaction with impact speed affect the severity of contusion spinal cord injury in rats.

J Neurotrauma. 2014-12-15

[3]
Conversion Equation between the Drop Height in the New York University Impactor and the Impact Force in the Infinite Horizon Impactor in the Contusion Spinal Cord Injury Model.

J Neurotrauma. 2015-12-15

[4]
Survival Model of Thoracic Contusion Spinal Cord Injury in the Domestic Pig.

J Neurotrauma. 2023-5

[5]
Finite element analysis of spinal cord injury in the rat.

J Neurotrauma. 2008-7

[6]
Behavioral and anatomical consequences of repetitive mild thoracic spinal cord contusion injury in the rat.

Exp Neurol. 2014-4-28

[7]
Effects of a contusion load on spinal cord with different curvatures.

Comput Methods Biomech Biomed Engin. 2021-9

[8]
Maximum principal strain correlates with spinal cord tissue damage in contusion and dislocation injuries in the rat cervical spine.

J Neurotrauma. 2012-4-18

[9]
Effects of contusion load on cervical spinal cord: A finite element study.

Math Biosci Eng. 2020-1-16

[10]
Effect of experimental, morphological and mechanical factors on the murine spinal cord subjected to transverse contusion: A finite element study.

PLoS One. 2020-5-11

引用本文的文献

[1]
Biomechanical evaluation on a new type of vertebral titanium porous mini-plate and mechanical comparison between cervical open-door laminoplasty and laminectomy: a finite element analysis.

Front Bioeng Biotechnol. 2024-2-5

[2]
Comparison of biomechanical parameters of two Chinese cervical spine rotation manipulations based on motion capture and finite element analysis.

Front Bioeng Biotechnol. 2023-7-27

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